Superoxide dismutase specific activities in cultured human diploid cells of various donor ages

Autor:	Michael R. Duncan, K. D. Kirk, Robert T. Dell'Orco
Rok vydání:	1979
Předmět:	Fetus Aging biology Physiology Superoxide Dismutase Clinical Biochemistry Cell Biology In vitro Enzyme assay WI-38 Cell Line Superoxide dismutase Andrology Biochemistry Cell culture biology.protein Humans Specific activity Electrophoresis Polyacrylamide Gel Lung Free-radical theory of aging Skin
Zdroj:	Journal of cellular physiology. 98(2)
ISSN:	0021-9541
Popis:	It has been postulated that superoxide dismutase (SOD) protects cells from free radical-induced damage. In these experiments SOD specific activity was measured as established human diploid cell lines from various donor ages progressed through their in vitro lifespan. Significant elevations in activity occurred during the in vitro lifespans of cells from fetal and newborn donors, but no change in activity was detected during the lifespan of cells from an adult donor. In addition, a direct relationship between enzyme activity and donor age was detected with the following relative activities: adult greater than newborn greater than fetal. The possible relationship between these findings and the free radical theory of aging is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6d6df5fea2af2eb7027c9ac5e82f71 https://pubmed.ncbi.nlm.nih.gov/422668 Zobrazit plný text záznamu Plný text