Tumor size before image-guided brachytherapy is an important factor of local control after radiotherapy for cervical squamous cell carcinoma: analysis in cases using central shielding
| Autor: | Kotaro Yoshio, Hiroki Ihara, Kazuhiro Okamoto, Etsuji Suzuki, Takeshi Ogata, Soichi Sugiyama, Keiichiro Nakamura, Shoji Nagao, Hisashi Masuyama, Takao Hiraki |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
squamous cell carcinoma
Radiation cervical cancer Health Toxicology and Mutagenesis Radiotherapy Planning Computer-Assisted tumor size Brachytherapy Uterine Cervical Neoplasms Bone Neoplasms Breast Neoplasms image-guided brachytherapy (IGBT) Carcinoma Squamous Cell central shielding (CS) Humans Radiology Nuclear Medicine and imaging Female Tomography X-Ray Computed |
| Zdroj: | Journal Of Radiation Research. |
| ISSN: | 0449-3060 |
| Popis: | We analyzed the local control (LC) of cervical squamous cell carcinoma treated by computed tomography (CT)-based image-guided brachytherapy (IGBT) using central shielding (CS). We also examined the value of tumor diameter before brachytherapy (BT) as a factor of LC. In total, 97 patients were analyzed between April 2016 and March 2020. Whole-pelvic (WP) radiotherapy (RT) with CS was performed, and the total pelvic sidewall dose was 50 or 50.4 Gy; IGBT was delivered in 3–4 fractions. The total dose was calculated as the biologically equivalent dose in 2 Gy fractions, and distribution was modified manually by graphical optimization. The median follow-up period was 31.8 months (6.3–63.2 months). The 1- and 2-year LC rates were 89% and 87%, respectively. The hazard ratio was 10.11 (95% confidence interval: 1.48–68.99) for local recurrence in those with a horizontal tumor diameter ≥ 4 cm compared to those with < 4 cm before BT. In CT-based IGBT for squamous cell carcinoma, favorable LC can be obtained in patients with a tumor diameter |
| Databáze: | OpenAIRE |
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