Relative contributions of diabetes and chronic kidney disease to neuropathy development in diabetic nephropathy patients
| Autor: | Susan Walker, Matthew C. Kiernan, Ria Arnold, Tushar Issar, Natalie Kwai, Bruce A. Pussell, Adeniyi A. Borire, Arun V. Krishnan, Ann M. Poynten, Aimy Yan, Zoltan H. Endre |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Diabetic neuropathy Models Neurological Neural Conduction Type 2 diabetes Disease urologic and male genital diseases 050105 experimental psychology Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Diabetic Neuropathies Physiology (medical) Internal medicine Diabetes mellitus Humans Medicine Diabetic Nephropathies 0501 psychology and cognitive sciences Renal Insufficiency Chronic Aged business.industry 05 social sciences Middle Aged medicine.disease Axons Sensory Systems Pathophysiology Diabetes Mellitus Type 2 Neurology Case-Control Studies Female Neurology (clinical) business 030217 neurology & neurosurgery Kidney disease Nerve excitability |
| Zdroj: | Clinical Neurophysiology. 130:2088-2095 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2019.08.005 |
| Popis: | Chronic kidney disease (CKD) caused by diabetes is known as diabetic kidney disease (DKD). The present study aimed to examine the underlying mechanisms of axonal dysfunction and features of neuropathy in DKD compared to CKD and type 2 diabetes (T2DM) alone.Patients with DKD (n = 30), CKD (n = 28) or T2DM (n = 40) and healthy controls (n = 41) underwent nerve excitability assessments to examine axonal function. Neuropathy was assessed using the Total Neuropathy Score. A validated mathematical model of human axons was utilised to provide an indication of the underlying causes of nerve pathophysiology.Total neuropathy score was significantly higher in patients with DKD compared to those with either CKD or T2DM (p 0.05). In DKD, nerve excitability measures (S2 accommodation and superexcitability, p 0.05) were more severely affected compared to both CKD and T2DM and worsened with increasing serum KPatients with DKD manifested a more severe neuropathy phenotype and shared features of nerve dysfunction to that of CKD.The CKD, and not diabetes component, appears to underlie axonal pathophysiology in DKD. |
| Databáze: | OpenAIRE |
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