Serum type I and type III procollagen peptide levels in sarcoidosis
| Autor: | Carlo Aprile, Giuseppe Cetta, V. Peona, M. Luisetti, L. Bacchella, LS Gile, L. Pasturenzi, Carmine Tinelli, Marina Gorrini |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Systemic disease Sarcoidosis Peptide macromolecular substances Sensitivity and Specificity Bone Morphogenetic Protein 1 Fibrosis Internal medicine medicine Humans chemistry.chemical_classification Analysis of Variance Lung integumentary system biology business.industry Metalloendopeptidases Angiotensin-converting enzyme Radioimmunoassay Middle Aged medicine.disease Peptide Fragments Procollagen peptidase Cross-Sectional Studies Endocrinology medicine.anatomical_structure chemistry Bone Morphogenetic Proteins biology.protein Female business Procollagen |
| Zdroj: | European Respiratory Journal. 9:1648-1651 |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | Type I and type III are the most abundant collagens in the lung. The aim of our study was to compare type I and III procollagen peptides in sera of sarcoid patients. Sixty eight patients with sarcoidosis were studied (19 with newly recognized disease, 7 with relapsing disease, 15 with chronic disease, and 27 in stable remission). Thirty healthy volunteers served as controls. The levels of procollagen I and III peptides were determined by radioimmunoassay. Angiotensin-converting enzyme (ACE) level was evaluated by means of a colorimetric assay. In patients with newly recognized sarcoidosis, both serum procollagen I and III peptide levels were increased with respect to controls (p=0.0014 and p |
| Databáze: | OpenAIRE |
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