Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection
| Autor: | Christopher C. Kemball, Christian P. Larsen, Leigh A. O’Mara, Thomas C. Pearson, David Masopust, Rafi Ahmed, Aron E. Lukacher, Daniel L. Barber, Vaiva Vezys |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
T cell
Immunology CD8-Positive T-Lymphocytes Mice 03 medical and health sciences Interleukin 21 0302 clinical medicine Antigen medicine Animals Lymphocytic choriomeningitis virus Immunology and Allergy Cytotoxic T cell Antigen-presenting cell Antigens Viral 030304 developmental biology 0303 health sciences CD40 biology Brief Definitive Report Cell Differentiation Flow Cytometry Natural killer T cell Virology 3. Good health Mice Inbred C57BL medicine.anatomical_structure Virus Diseases Interleukin 12 biology.protein Brief Definitive Reports Female Polyomavirus 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20060995 |
| Popis: | Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T cell activation. Pathogen-specific T cells in chronically infected hosts are often phenotypically and functionally variable, as well as distinct from T cells responding to nonpersistent infections; this phenotypic heterogeneity has been attributed to an ongoing reencounter with antigen. Paradoxically, maintenance of memory CD8 T cells to acutely resolved infections is antigen independent, whereas there is a dependence on antigen for T cell survival in chronically infected hosts. Using two chronic viral infections, we demonstrate that new naive antigen-specific CD8 T cells are primed after the acute phase of infection. These newly recruited T cells are phenotypically distinct from those primed earlier. Long-lived antiviral CD8 T cells are defective in self-renewal, and lack of thymic output results in the decline of virus-specific CD8 T cells, indicating that newly generated T cells preserve antiviral CD8 T cell populations during chronic infection. These findings reveal a novel role for antigen in maintaining virus-specific CD8 T cells during persistent infection and provide insight toward understanding T cell differentiation in chronic infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|