Clinical periodontal status and inflammatory cytokines in gestational diabetes mellitus
| Autor: | Ayse Nalbantsoy, Banu Ceyhan-Öztürk, Pınar Gümüş, Nurcan Buduneli, Aliye Akcalı, Özgün Özçaka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Necrosis Bleeding on probing Inflammation Gastroenterology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine medicine Humans General Dentistry 030219 obstetrics & reproductive medicine business.industry Tumor Necrosis Factor-alpha Dental Plaque Index 030206 dentistry Cell Biology General Medicine Gingival Crevicular Fluid medicine.disease Interleukin-33 Interleukin-10 Gestational diabetes Diabetes Gestational Cross-Sectional Studies Otorhinolaryngology Immunology Smoking status Female medicine.symptom business Body mass index |
| Popis: | The aim of the present cross-sectional study was to compare clinical periodontal findings as well as gingival crevicular fluid (GCF) and serum levels of tumour necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), and IL-33 between women with and without gestational diabetes mellitus (GDM).Serum and GCF samples were collected, full-mouth recordings comprising plaque index, bleeding on probing and probing depth were performed in 96 females with GDM (cases) and 65 non-diabetic pregnant females (controls). Age, smoking status, pre-pregnancy body mass index, pregnancy outcomes were recorded. Serum and GCF IL-10, IL-33, TNF-α levels were determined.The GDM group was significantly older than the control group with an age difference of 3.27 years (mean ages were 32.05 and 28.78 years, respectively) (p0.0001). Plaque Index (50.0 and 30.0 p=0.005), bleeding on probing (50.0 and 30.0 p=0.003) values were significantly higher in the GDM group. Serum TNF-α concentrations were significantly higher in the nonGDM group than the GDM group (p=0.001). GCF IL-10 concentrations and total amounts were significantly higher in the GDM group than the controls (p=0.004 and p0.0001, respectively).Elevated GCF IL-10 levels may be a consequence of higher levels of inflammation as indicated by higher PI and BOP in the GDM group. However, the investigated clinical parameters may not have prominent effects on TNF-α and IL-33 levels. These findings provide further support for the importance of periodontal health during pregnancy. |
| Databáze: | OpenAIRE |
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