Prognostic value of lymph node micrometastasis in patients with colorectal cancer in Dukes stages A and B (T1-T4, N0, M0)
| Autor: | J Fuentes, J Ortego, N Raventós, Rafael Uribarrena-Amezaga, P Parra, R Uribarrena-Echevarría |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Dukes stage Pathology Colorectal cancer Kaplan-Meier Estimate Colorectal adenocarcinoma Internal medicine medicine Humans In patient Lymph node Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Gastroenterology General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry humanities Micrometastases Tumor recurrence medicine.anatomical_structure Lymphatic Metastasis Female Lymph Nodes business Colorectal Neoplasms |
| Zdroj: | Revista Española de Enfermedades Digestivas v.102 n.3 2010 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname |
| ISSN: | 1130-0108 |
| Popis: | Background: 30% of patients with colorectal cancer (CRC) in Dukes stages A and B (T1-T4, N0, M0) present tumor recurrence and die after 5 years follow up. This unexpectedly poor evolution might be attributable to the presence of lymph node micrometastasis undetected in routine examination with haematoxilin-eosine (H&E). Objective: to assess the presence of undetected micrometastasis. Patients and methods: we conducted a retrospective study of the locoregional lymph nodes in 85 patients operated for CRC in Dukes stages A and B (T1-T4, N0, M0), using immunohistochemistry with anticytokeratin antibodies AE1/AE3. In this descriptive, inferential bivariant and survival study, we analyzed different risk factors, including local infiltration T1/T4, Dukes A/B, number of dissected lymph nodes, vascular invasion, micrometastasis, tumor recurrence and death in the context of the presence or absence of micrometastases. Results: Dukes stage and neoplastic angioinvasion are influential in patient prognosis; however, lymph node micrometastases were not associated with a poorer outcome of CRC. Conclusions: locorregional lymph node micrometastases detected with anticytokeratine antibodies AE1/AE3 in Dukes A and B CRC patients are not associated with reduced survival. |
| Databáze: | OpenAIRE |
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