Tuliposides H–J and Bioactive Components from the Bulb of Amana edulis
| Autor: | Yuan-Shiun Chang, Yun-Lian Jhan, Chia Lin Lee, Zhi-An Gao, Chao-Jung Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Tyrosinase
Phytochemicals Melanoma Experimental Pharmaceutical Science Organic chemistry Furfural Article Analytical Chemistry Melanin chemistry.chemical_compound Mice QD241-441 bulb Glucosides Drug Discovery medicine Liliaceae Tumor Cells Cultured Animals Hydroxymethyl melanogenesis regulation Physical and Theoretical Chemistry Hypopigmentation Melanins biology integumentary system Monophenol Monooxygenase Plant Extracts biology.organism_classification Amana edulis Bulb chemistry Chemistry (miscellaneous) Molecular Medicine tuliposides H–J medicine.symptom Nuclear chemistry |
| Zdroj: | Molecules Molecules, Vol 26, Iss 5907, p 5907 (2021) Volume 26 Issue 19 |
| ISSN: | 1420-3049 |
| Popis: | Three new tuliposides H–J (1–3) and 11 known compounds were obtained from the methanolic extracts of the bulbs of Amana edulis for the first time. Their structures were elucidated by NMR, MS, and IR spectroscopic data, optical rotation, and Mosher’s method. The melanogenesis properties of all the isolates were evaluated in B16 melanoma cells. Consequently, tributyl citrate (9) had anti-melanogenesis activity but was cytotoxic toward B16. (+)-Pyroglutamic acid (4), (+)-butyl 5-oxopyrrolidine-2-carboxylate (6), (–)-3-hydroxy-2-methylbutyrolactone (10), and 5-(hydroxymethyl)furfural (12) had increased melanin productions and tyrosinase activities. Those active components could be further studied as the candidates against melanoma and vitiligo for skin diseases or whitening/hypopigmentation for hair. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|