Blunted Pain Modulation Response to Induced Stress in Women with Fibromyalgia with and without Posttraumatic Stress Disorder Comorbidity: New Evidence of Hypo-Reactivity to Stress in Fibromyalgia?
| Autor: | Almudena López-López, Borja Matías-Pompa, J. L. González Gutiérrez, Miriam Alonso-Fernández, J.L. Alonso Perez, Josué Fernández-Carnero, Alfonso Gil-Martínez |
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| Rok vydání: | 2020 |
| Předmět: |
Pain Threshold
Causalgia medicine.medical_specialty Fibromyalgia Pain tolerance Enfermedad cardiovascular Comorbidity Stress Disorders Post-Traumatic Stress (mechanics) 03 medical and health sciences 0302 clinical medicine Internal medicine Threshold of pain medicine Humans 030212 general & internal medicine Reactivity (psychology) Applied Psychology Pain modulation 030505 public health business.industry Estrés mental Fibromialgia medicine.disease Trastornos por estrés postraumático Psychiatry and Mental health Posttraumatic stress Endocrinology Female Chronic Pain 0305 other medical science business |
| Zdroj: | Behavioral Medicine. 47:311-323 |
| ISSN: | 1940-4026 0896-4289 |
| DOI: | 10.1080/08964289.2020.1758611 |
| Popis: | There is evidence regarding the presence of alterations in both the stress response and the endogenous pain modulation systems of people with fibromyalgia (FM). However, research on pain modulation under induced stress on FM patients is scarce and contradictory. The present study analyzes stress-induced changes in pain and intolerance thresholds among FM patients, examining the possible existence of differences linked to PTSD comorbidity and gaining insights into the role of cardiovascular reactivity. Eighteen women diagnosed with FM and comorbid PTSD (FM + PTSD), 18 women diagnosed with FM and no PTSD (FM-PTSD), and 38 healthy women (HC) were exposed to the Social Stress Test task. Pressure pain thresholds and intolerance thresholds were measured before and during stress induction, and after a recovery period, while systolic blood pressure and heart rate were simultaneously recorded. Overall, while pain thresholds decreased during stress and recovery for HC, no significant changes were observed for women with FM. The intolerance threshold decreased for HC during stress, but was maintained at basal level during recovery. FM-PTSD women exhibited a delayed response, with a drop at recovery. For FM + PTSD, tolerance levels remained unchanged. In addition, cardiovascular reactivity did not seem to explain these results. This performance of the pain modulation system seems to follow the same pattern of hypoactive responsiveness under stressors that has previously been observed in FM patients on the autonomic and neuroendocrine axes. Such a hypoactive pattern may involve a non-adaptive response that may contribute to the development and maintenance of chronic pain. Ministerio de Economia, Industria y Competitividad, Gobierno de España (under Grant PSI2010-21888) 3.104 JCR (2020) Q2, 23/53 Behavioral Sciences 0.896 SJR (2020) Q2, 177/537 Psychiatry and Mental Health No data IDR 2020 UEM |
| Databáze: | OpenAIRE |
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