Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats

Autor: Véronique Pallet, Paul Higueret, Serge Alfos, Djoher Nora Abrous, Emilie Bonnet, Katia Touyarot
Přispěvatelé: Psychoneuroimmunologie, nutrition et génétique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux Ségalen [Bordeaux 2], Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2008
Předmět:
[SDV]Life Sciences [q-bio]
Retinoic acid
lcsh:Medicine
Water maze
Hippocampal formation
rattus rattus
Hippocampus
chemistry.chemical_compound
mémoire
Retinoid
vitamine a
lcsh:Science
récepteur nucléaire
Multidisciplinary
Neuroscience/Behavioral Neuroscience
Vitamin A Deficiency
Neuroscience/Neuronal and Glial Cell Biology
Neurogenesis
Neuroscience/Animal Cognition
Nutrition/Deficiencies
Up-Regulation
Treatment Outcome
plasticité synaptique
acide rétinoïque
medicine.drug
Neurotrophin
expression des gènes
Research Article
medicine.medical_specialty
neurogénèse
trouble du comportement
medicine.drug_class
Tretinoin
Biology
pcr
Internal medicine
medicine
Neuroscience/Neuronal Signaling Mechanisms
Animals
Regeneration
Receptor
trkA
Nutrition
carence
Memory Disorders
lcsh:R
medicine.disease
Rats
Vitamin A deficiency
Endocrinology
chemistry
biology.protein
lcsh:Q
Zdroj: PLoS ONE
PLoS ONE, Public Library of Science, 2008, 3 (10), 10 p. ⟨10.1371/journal.pone.0003487⟩
PLoS ONE, Vol 3, Iss 10, p e3487 (2008)
Plos One 10 (3), 10 p.. (2008)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0003487⟩
Popis: A dysfunction of retinoid hippocampal signaling pathway has been involved in the appearance of affective and cognitive disorders. However, the underlying neurobiological mechanisms remain unknown. Hippocampal granule neurons are generated throughout life and are involved in emotion and memory. Here, we investigated the effects of vitamin A deficiency (VAD) on neurogenesis and memory and the ability of retinoic acid (RA) treatment to prevent VAD-induced impairments. Adult retinoid-deficient rats were generated by a vitamin A-free diet from weaning in order to allow a normal development. The effects of VAD and/or RA administration were examined on hippocampal neurogenesis, retinoid target genes such as neurotrophin receptors and spatial reference memory measured in the water maze. Long-term VAD decreased neurogenesis and led to memory deficits. More importantly, these effects were reversed by 4 weeks of RA treatment. These beneficial effects may be in part related to an up-regulation of retinoid-mediated molecular events, such as the expression of the neurotrophin receptor TrkA. We have demonstrated for the first time that the effect of vitamin A deficient diet on the level of hippoccampal neurogenesis is reversible and that RA treatment is important for the maintenance of the hippocampal plasticity and function.
Databáze: OpenAIRE
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