Rapid and complete urinary elimination of [14C]-5-hydroxymethyl-2-furaldehyde administered orally or intravenously to rats
| Autor: | Jacques-Edouard Germond, U. Richli, Maurice J. Arnaud, Ingrid Bracco, Georges Philippossian |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Chromatography Dose-Response Relationship Drug Furaldehyde Glycine Administration Oral Fructose Rats Inbred Strains Urine Metabolism Toxicology Pollution Rats Excretion chemistry.chemical_compound chemistry Oral administration Injections Intravenous Organic chemistry Animals Hydroxymethyl Tissue Distribution Carbon Radioisotopes |
| Zdroj: | Journal of toxicology and environmental health. 22(1) |
| ISSN: | 0098-4108 |
| Popis: | 5-Hydroxymethyl-2-furaldehyde (HMF), is a major product of sugar degradation found in food and solutions used in parenteral nutrition. Labeled [14C]HMF was synthesized by dehydration of [14C]fructose on ion-exchange resin and administered per os (po) and intravenously (iv) to rats. Metabolic balance of radioactivity demonstrated that HMF or its metabolites are rapidly eliminated in the urine with a recovery of 95-100% after 24 h. Literature reported, in some cases, 50% retention in the body. HMF was completely converted to two metabolites, which have been identified by nuclear magnetic resonance (NMR) and mass spectroscopy (MS) as 5-hydroxymethyl-2-furoic acid and N-(5-hydroxymethyl-2-furoyl)glycine. Administration of high doses of HMF showed a similar rapid elimination, but a proportional reduction of the amount of the glycine conjugate produced. Whole-animal-body autoradiography confirm that shortly after administration radioactive material was present in the liver but was mostly in the kidney and the bladder. The only significant difference between po and iv administration was the presence of a higher level of radioactive material in the brain of iv-treated rats. |
| Databáze: | OpenAIRE |
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