Effects of Lactobacillus Fermented Soymilk and Soy Yogurt on Hepatic Lipid Accumulation in Rats Fed a Cholesterol-Free Diet
| Autor: | Yuko Nishimura, Naohiro Takagi, Ryoko Kitawaki, Mitsuhiro Iwasaki, Mitsuru Fukuda, Kimiko Tsuzuki |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Adipose tissue Biology Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Bile Acids and Salts Cholesterol Dietary Rats Sprague-Dawley Eating Feces chemistry.chemical_compound Lactobacillus Soy yogurt Animals Ingestion Lactic Acid Food science Molecular Biology Oligonucleotide Array Sequence Analysis Cholesterol Body Weight Organic Chemistry food and beverages Organ Size General Medicine Lipid Metabolism Yogurt biology.organism_classification Lipids Diet Rats Soy Milk Lactic acid Gene Expression Regulation Liver chemistry Fermentation Lipogenesis Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 73:1484-1488 |
| ISSN: | 1347-6947 0916-8451 |
| Popis: | We examined the effects of lactic acid fermented soymilk, in which part of the soymilk was replaced with okara (soy yogurt), on plasma and hepatic lipid profiles in rats fed a cholesterol-free diet. Additionally, we investigated the effects of soy yogurt on hepatic gene expression in rats using DNA microarray analysis. Male Sprague-Dawley rats aged 5 weeks (n=5/group) were fed a control diet (AIN-93) or a test diet in which 20% of the diet was replaced by soy yogurt for 7 weeks. Soy yogurt consumption did not affect body weight or adipose tissue weight as compared with control diet. In the soy yogurt group, the liver weight and hepatic triglyceride content were significantly lower than the control group, and the level of plasma cholesterol was also lower. Furthermore, DNA microarray analysis indicated that soy yogurt ingestion down-regulated the expression of the SREBP-1 gene and enzymes related to lipogenesis in the rat liver, while expression of beta-oxidation-related genes was up-regulated. These results suggest that soy yogurt is beneficial in preventing hepatic lipid accumulation in rats. |
| Databáze: | OpenAIRE |
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