Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
| Autor: | Russo, M., Carrarini, Claudia, Di Iorio, A., Pellegrino, R., Bruni, A. C., Caratozzolo, S., Chiari, A., Pretta, S., Marra, Camillo, Cotelli, M. S., Arighi, A., Fumagalli, G. G., Cataruzza, T., Caso, F., Paci, C., Rosso, M., Amici, S., Giannandrea, D., Pilotto, A., Luzzi, S., Castellano, A., D'Antonio, F., Luca, A., Gelosa, G., Piccoli, T., Mauri, M., Agosta, F., Babiloni, C., Borroni, B., Bozzali, M., Filippi, M., Galimberti, D., Monastero, R., Muscio, C., Parnetti, L., Perani, D., Serra, L., Silani, V., Tiraboschi, P., Cagnin, A., Padovani, A., Bonanni, L., Roberta, B., Federica, F., Sebastiano, G., Caterina, G., Gianmarco, G., Giuseppe, M., Giulia, M., Stefano, M., Carmela, R., Marco, R., Pierpaolo, S., Giuseppe, S. P., Marinella, T., Federico, V., Antonietta, V. M. |
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| Přispěvatelé: | Russo, Mirella, Carrarini, Claudia, Di Iorio, Angelo, Pellegrino, Raffaello, Bruni, Amalia Cecilia, Caratozzolo, Salvatore, Chiari, Annalisa, Pretta, Stefano, Marra, Camillo, Cotelli, Maria Sofia, Arighi, Andrea, Fumagalli, Giorgio G, Cataruzza, Tatiana, Caso, Francesca, Paci, Cristina, Rosso, Mara, Amici, Serena, Giannandrea, David, Pilotto, Andrea, Luzzi, Simona, Castellano, Annalisa, D'Antonio, Fabrizia, Luca, Antonina, Gelosa, Giorgio, Piccoli, Tommaso, Mauri, Marco, Agosta, Federica, Babiloni, Claudio, Borroni, Barbara, Bozzali, Marco, Filippi, Massimo, Galimberti, Daniela, Monastero, Roberto, Muscio, Cristina, Parnetti, Lucilla, Perani, Daniela, Serra, Laura, Silani, Vincenzo, Tiraboschi, Pietro, Cagnin, Annachiara, Padovani, Alessandro, Bonanni, Laura, D'antonio, Fabrizia |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Lewy Body Disease
Clinical diagnosi Dementia with Lewy bodie Consensus criteria Dementia with Lewy bodies Dermatology behavioral disciplines and activities Diagnostic accuracy Diagnosis Differential Alzheimer Disease Diagnosis mental disorders Humans Reproducibility of Results Diagnostic toolkit General Medicine Clinical diagnosis Cognitive impairment Dementia Diagnostic toolkits nervous system diseases Settore MED/26 - NEUROLOGIA Psychiatry and Mental health Italy Differential Neurology (clinical) |
| Popis: | Introduction: Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB). We aim to evaluate the reliability of these two questionnaires, and their ability to enhance the interpretation of the international consensus diagnostic criteria. Methods: LBCRS and AT-DLB were distributed to 135 Italian Neurological Centers for Cognitive Decline and Dementia (CDCDs), with the indication to administer them to all patients with dementia referred within the subsequent 3months. We asked to subsequently apply consensus criteria for DLB diagnosis, to validate the diagnostic accuracy of the two toolkits. Results: A total of 23 Centers joined the study; 1854 patients were enrolled. We found a prevalence of possible or probable DLB of 13% each (26% total), according to the consensus criteria. LBCRS toolkit showed good reliability, with a Cronbach alpha of 0.77, stable even after removing variables from the construct. AT-DLB toolkit Cronbach alpha was 0.52 and, after the subtraction of the "cognitive fluctuation" criterion, was only 0.31. Accuracy, sensitivity, and specificity were higher for LBCRS vs. AT-DLB. However, when simultaneously considered in the logistic models, AT-DLB showed a better performance (p |
| Databáze: | OpenAIRE |
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