Dexamethasone Reduces the Incidence of Postoperative Nausea and Vomiting in Children Undergoing Endoscopic Adenoidectomy under General Anesthesia Without Increasing the Risk of Postoperative Hemorrhage
Autor: | Jan Divák, Vojtěch Vodička, Ondřej Jor, Michaela Masárová, Roman Gál, Michal Frelich |
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Rok vydání: | 2018 |
Předmět: |
Male
Nausea medicine.medical_treatment Anesthesia General Postoperative Hemorrhage Placebo Dexamethasone Adenoidectomy 03 medical and health sciences Postoperative Complications 0302 clinical medicine Double-Blind Method Clinical Research 030202 anesthesiology medicine Humans Retching Prospective Studies 030212 general & internal medicine Child Prospective cohort study business.industry Incidence Endoscopy General Medicine Child Preschool Anesthesia Postoperative Nausea and Vomiting FLACC scale Vomiting Antiemetics Female medicine.symptom business Postoperative nausea and vomiting |
Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
ISSN: | 1643-3750 |
Popis: | BACKGROUND Postoperative nausea and vomiting (PONV) is a common complication of pediatric anesthesia, but the overall incidence of PONV in patients undergoing adenoidectomy is unknown. The aim of this controlled study was to compare the effect of dexamethasone administration with placebo to reduce PONV in children undergoing endoscopic adenoidectomy under general anesthesia. MATERIAL AND METHODS A randomized placebo-controlled study included 118 pediatric patients who underwent elective endoscopic adenoidectomy under general anesthesia. A dexamethasone-treated (0.15 mg/kg) group (Group D) (n=56) and a placebo group (Group C) (n=62) were randomly assigned. The incidence of nausea and vomiting was recorded on the day of surgery. Postoperative nausea was assessed according to illustrated Baxter Animated Retching Faces (BARF) scale. The Face, Legs, Activity, Cry, and Consolability (FLACC) scale (scores between 0-10) was used to assess pain. Follow-up was performed on the 14th postoperative day by a telephone call. RESULTS Overall prevalence of postoperative nausea was 25% (30/118) and postoperative vomiting was 14% (17/118). In the first 24 hours following surgery, in Group D, the incidence of nausea and vomiting was 13% and 7%, respectively; in Group C, without pharmacological prophylaxis, the incidence of postoperative nausea and vomiting was 37%, and 21%, respectively. CONCLUSIONS A prospective controlled study in children undergoing endoscopic adenoidectomy under general anesthesia showed that dexamethasone (0.15 mg/kg) significantly reduced the incidence of PONV without increasing the risk of postoperative hemorrhage. Dexamethasone is a safe method for the prevention of PONV that may be recommended in pediatric anesthesiology. |
Databáze: | OpenAIRE |
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