Dosimetric comparison of different treatment modalities for stereotactic radiosurgery of meningioma

Autor: David, Kaul, Harun, Badakhshi, Thierry, Gevaert, Diana, Pasemann, Volker, Budach, Constantin, Tuleasca, Constantin, Tulaesca, Arne, Gruen, Vikas, Prasad, Marc, Levivier, Markus, Kufeld
Přispěvatelé: Clinical sciences
Rok vydání: 2014
Předmět:
Zdroj: Acta neurochirurgica. 157(4)
ISSN: 0942-0940
Popis: Background The objective of this study was to compare the three most prominent systems for stereotactic radiosurgery in terms of dosimetric characteristics:the Cyberknife system, the Gamma Knife Perfexion and the Novalis system. Methods Ten patients treated for recurrent grade I meningioma after surgery using the Cyberknife system were identified; the Cyberknife contours were exported and comparative treatmentplansweregeneratedfortheNovalissystemandGamma Knife Perfexion. Dosimetric values were compared with respect to coverage, conformity index (CI), gradient index (GI) and beam-on time (BOT). Results All three systems showed comparable results in terms of coverage. The Gamma Knife and the Cyberknife system showed significantly higher levels of conformity than the Novalis system (Cyberknife vs Novalis, p=0.002; Gamma Knife vs Novalis, p=0.002). The Gamma Knife showed significantlysteepergradientscomparedwiththeNovalisand the Cyberknife system (Gamma Knife vs Novalis, p=0.014; Gamma Knife vs Cyberknife, p=0.002) and significantly longer beam-on times than the other two systems (BOT=66 ±21.3 min, Gamma Knife vs Novalis, p=0.002; Gamma Knife vs Cyberknife, p=0.002). Conclusions The multiple focal entry systems (Gamma Knife and Cyberknife) achieve higher conformity than the Novalis system. The Gamma Knife delivers the steepest dose gradient of all examined systems. However, the Gamma Knife is known to require long beam-on times, and despite worse dose gradients, LINAC-based systems (Novalis and Cyberknife) offer image verification at the time of treatment delivery.
Databáze: OpenAIRE
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