Multi-sensory (auditory and somatosensory) pre-pulse inhibition in mice
| Autor: | Mark L. Gabriele, Lincoln Gray, Anna Louthan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Reflex
Startle Startle response medicine.medical_specialty media_common.quotation_subject Experimental and Cognitive Psychology Stimulation Audiology Somatosensory system Article Mice 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Multi sensory Perception medicine Psychophysics Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology media_common medicine.diagnostic_test Prepulse Inhibition business.industry 05 social sciences Neural Inhibition medicine.disease Mice Inbred C57BL Acoustic Stimulation Autism medicine.symptom business 030217 neurology & neurosurgery Tinnitus |
| Zdroj: | Physiol Behav |
| ISSN: | 0031-9384 |
| Popis: | We investigated the perception of two mechanoreceptive modalities alone and in combination: main effects and interaction between auditory and somatosensory stimulation in mice. Fifteen C57BL/6J mice between the ages of 1 and 6 months were tested three times each. Experimental design roughly followed published procedures using pre-pulse inhibition (PPI) of the acoustic startle response, except pre-pulses included vibration of the test chamber as well as soft sounds. Auditory pre-pulses were 80 dB broadband noises of 4, 9, 25, or 45 ms duration. Vibrations were of the same duration but of different frequencies (500, 460, 360, and 220 Hz). Pre-pulse inhibition increased with duration of the auditory pre-pulses, as expected. There was significant PPI to some but not all vibrotactile pre-pulses. Multimodal PPI was approximately additive (no significant auditory-by-somatosensory interaction). PPI increased more with age to somatosensory than to auditory pre-pulses. Future studies of multi-modal psychophysics in various mouse mutants could lend support to more mechanistic studies of neural specificity and possibly autism, tinnitus, and PTSD. |
| Databáze: | OpenAIRE |
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