Increase of natural killer cells in children with liver transplantation-acquired food allergy
| Autor: | Neri Pucci, Alessandro Casini, Antonella Cianferoni, C. Angelucci, Elio Novembre, Giuseppe Indolfi, Francesca Mori, Chiara Azzari, M. Materassi, Giusi Mangone, Simona Barni |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Allergy medicine.medical_specialty medicine.medical_treatment Immunology 030232 urology & nephrology 030230 surgery Liver transplantation Gastroenterology Tacrolimus Mycophenolic acid Immunocompromised Host 03 medical and health sciences 0302 clinical medicine Food allergy Internal medicine medicine Humans Immunology and Allergy Child Kidney transplantation Immunosuppression Therapy business.industry Infant Immunosuppression General Medicine Mycophenolic Acid medicine.disease Liver Transplantation Killer Cells Natural Transplantation surgical procedures operative Child Preschool Female business Food Hypersensitivity Immunosuppressive Agents medicine.drug |
| Zdroj: | Allergologia et Immunopathologia. 46:447-453 |
| ISSN: | 0301-0546 |
| DOI: | 10.1016/j.aller.2017.09.030 |
| Popis: | Transplantation-acquired food allergies (TAFA) are frequently reported and considered to be caused by immunosuppressive therapy. The aim of this study was to investigate the allergic and immunologic responses in children who had liver or kidney transplantations.Twelve children receiving liver transplantations and 10 children receiving kidney transplantations were investigated. All children underwent the allergy work-up and in most of them, lymphocyte screening and serum cytokine measurements were also performed.TAFA were found in 7/12 (58%) children with liver transplantations and in none of the 10 children with kidney transplantations. The mean age at transplantation was significantly lower in children who underwent liver transplantations (p0.001). The immunosuppressive therapy administered to children with liver transplantation was tacrolimus in 11 patients and cyclosporine in one patient, while all 10 children with kidney transplantation received tacrolimus plus mycophenolate. The most common antigenic food was egg. The natural killer (NK) cell numbers were significantly higher in liver-transplant children than in kidney-transplant children. No significant differences were found in the serum cytokine levels.This study confirms that liver-transplant children treated with tacrolimus alone have a higher risk of developing TAFA than kidney-transplant children treated with tacrolimus plus mycophenolate. NK cells might be involved in this difference. |
| Databáze: | OpenAIRE |
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