Chemical Composition of a Novel Distillate from Fermented Mixture of Nine Anti-Inflammatory Herbs and Its UVB-Protective Efficacy in Mouse Dorsal Skin via Attenuating Collagen Disruption and Inflammation
Autor: | Hyun Sook Kim, Tae-Kyeong Lee, Hyun Sam Lee, Young Her, Moo-Ho Won, Ji Hyeon Ahn, Bora Kim, Tae Heung Sim, Jae-Chul Lee, Soon Sung Lim, Beom Goo Kang, Hyejin Sim, Jung-Seok Park |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Limosilactobacillus fermentum
distillation skin protection Ultraviolet Rays Lactobacillus fermentum medicine.drug_class Anti-Inflammatory Agents Pharmaceutical Science natural herb complex complex mixtures Article Anti-inflammatory Analytical Chemistry Proinflammatory cytokine lcsh:QD241-441 Mice 03 medical and health sciences 0302 clinical medicine Ulmus davidiana lcsh:Organic chemistry Drug Discovery medicine Animals Physical and Theoretical Chemistry fermentation Skin 030304 developmental biology Mice Inbred ICR 0303 health sciences Plants Medicinal biology Traditional medicine integumentary system Chemistry Organic Chemistry food and beverages biology.organism_classification Houttuynia cordata n/a Angelica gigas Chemistry (miscellaneous) 030220 oncology & carcinogenesis Molecular Medicine Collagen Hordeum vulgare Wound healing UVB Sunscreening Agents |
Zdroj: | Molecules Volume 26 Issue 1 Molecules, Vol 26, Iss 124, p 124 (2021) |
ISSN: | 1420-3049 |
DOI: | 10.3390/molecules26010124 |
Popis: | Since ancient times, various herbs have been used in Asia, including Korea, China, and Japan, for wound healing and antiaging of the skin. In this study, we manufactured and chemically analyzed a novel distillate obtained from a fermented mixture of nine anti-inflammatory herbs (Angelica gigas, Lonicera japonica, Dictamnus dasycarpus Turcz., D. opposita Thunb., Ulmus davidiana var. japonica, Hordeum vulgare var. hexastichon Aschers., Xanthium strumarium L., Cnidium officinale, and Houttuynia cordata Thunb.). The fermentation of natural plants possesses beneficial effects in living systems. These activities are attributed to the chemical conversion of the parent plants to functional constituents which show more potent biological activities. In our current study, the distillate has been manufactured after fermenting the nine oriental medical plants with Lactobacillus fermentum, followed by distilling. We analyzed the chemical ingredients involved in the distillate and evaluated the effects of topical application of the distillate on ultraviolet B (UVB)-induced skin damage in Institute of Cancer Research (ICR) mice. Topical application of the distillate significantly ameliorated the macroscopic and microscopic morphology of the dorsal skin against photodamage induced by UVB radiation. Additionally, our current results showed that topical application of the distillate alleviated collagen disruption and reduced levels of proinflammatory cytokines (tumor necrosis factor alpha and interleukin 1 &beta expressions) in the dorsal skin against UVB radiation. Taken together, our current findings suggest that the distillate has a potential to be used as a material to develop a photoprotective adjuvant. |
Databáze: | OpenAIRE |
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