Chemical Composition of a Novel Distillate from Fermented Mixture of Nine Anti-Inflammatory Herbs and Its UVB-Protective Efficacy in Mouse Dorsal Skin via Attenuating Collagen Disruption and Inflammation

Autor: Hyun Sook Kim, Tae-Kyeong Lee, Hyun Sam Lee, Young Her, Moo-Ho Won, Ji Hyeon Ahn, Bora Kim, Tae Heung Sim, Jae-Chul Lee, Soon Sung Lim, Beom Goo Kang, Hyejin Sim, Jung-Seok Park
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Limosilactobacillus fermentum
distillation
skin protection
Ultraviolet Rays
Lactobacillus fermentum
medicine.drug_class
Anti-Inflammatory Agents
Pharmaceutical Science
natural herb complex
complex mixtures
Article
Anti-inflammatory
Analytical Chemistry
Proinflammatory cytokine
lcsh:QD241-441
Mice
03 medical and health sciences
0302 clinical medicine
Ulmus davidiana
lcsh:Organic chemistry
Drug Discovery
medicine
Animals
Physical and Theoretical Chemistry
fermentation
Skin
030304 developmental biology
Mice
Inbred ICR
0303 health sciences
Plants
Medicinal
biology
Traditional medicine
integumentary system
Chemistry
Organic Chemistry
food and beverages
biology.organism_classification
Houttuynia cordata
n/a
Angelica gigas
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
Molecular Medicine
Collagen
Hordeum vulgare
Wound healing
UVB
Sunscreening Agents
Zdroj: Molecules
Volume 26
Issue 1
Molecules, Vol 26, Iss 124, p 124 (2021)
ISSN: 1420-3049
DOI: 10.3390/molecules26010124
Popis: Since ancient times, various herbs have been used in Asia, including Korea, China, and Japan, for wound healing and antiaging of the skin. In this study, we manufactured and chemically analyzed a novel distillate obtained from a fermented mixture of nine anti-inflammatory herbs (Angelica gigas, Lonicera japonica, Dictamnus dasycarpus Turcz., D. opposita Thunb., Ulmus davidiana var. japonica, Hordeum vulgare var. hexastichon Aschers., Xanthium strumarium L., Cnidium officinale, and Houttuynia cordata Thunb.). The fermentation of natural plants possesses beneficial effects in living systems. These activities are attributed to the chemical conversion of the parent plants to functional constituents which show more potent biological activities. In our current study, the distillate has been manufactured after fermenting the nine oriental medical plants with Lactobacillus fermentum, followed by distilling. We analyzed the chemical ingredients involved in the distillate and evaluated the effects of topical application of the distillate on ultraviolet B (UVB)-induced skin damage in Institute of Cancer Research (ICR) mice. Topical application of the distillate significantly ameliorated the macroscopic and microscopic morphology of the dorsal skin against photodamage induced by UVB radiation. Additionally, our current results showed that topical application of the distillate alleviated collagen disruption and reduced levels of proinflammatory cytokines (tumor necrosis factor alpha and interleukin 1 &beta
expressions) in the dorsal skin against UVB radiation. Taken together, our current findings suggest that the distillate has a potential to be used as a material to develop a photoprotective adjuvant.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje