Combined forced oscillation and fractional-order modeling in patients with work-related asthma: a case–control study analyzing respiratory biomechanics and diagnostic accuracy
| Autor: | Hermano Albuquerque de Castro, Pedro Lopes de Melo, Paula Morisco de Sá, Agnaldo José Lopes, Fábio Augusto d´Alegria Tuza |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male lcsh:Medical technology Extended RIC respiratory model Hysteresivity 0206 medical engineering Biomedical Engineering Diagnostic accuracy 02 engineering and technology Diagnostic of respiratory diseases Models Biological Biomedical instrumentation Respiratory biomechanics Biomaterials 03 medical and health sciences 0302 clinical medicine Forced Oscillation Technique Statistics Work-related asthma Humans Radiology Nuclear Medicine and imaging In patient Lung Mathematics Respiratory impedance Respiratory system modeling Radiological and Ultrasound Technology Receiver operating characteristic Research Case-control study Biomechanics General Medicine Middle Aged Respiratory oscillometry 020601 biomedical engineering Asthma Biomechanical Phenomena Forced oscillation technique 030228 respiratory system lcsh:R855-855.5 Case-Control Studies Curve fitting Respiratory Mechanics Fractional-order model Female Bronchodilator |
| Zdroj: | BioMedical Engineering OnLine, Vol 19, Iss 1, Pp 1-30 (2020) BioMedical Engineering |
| Popis: | BackgroundFractional-order (FrOr) models have a high potential to improve pulmonary science. These models could be useful for biomechanical studies and diagnostic purposes, offering accurate models with an improved ability to describe nature. This paper evaluates the performance of the Forced Oscillation (FO) associated with integer (InOr) and FrOr models in the analysis of respiratory alterations in work-related asthma (WRA).MethodsSixty-two individuals were evaluated: 31 healthy and 31 with WRA with mild obstruction. Patients were analyzed pre- and post-bronchodilation. The diagnostic accuracy was evaluated using the area under the receiver operating characteristic curve (AUC). To evaluate how well do the studied models correspond to observed data, we analyzed the mean square root of the sum (MSEt) and the relative distance (Rd) of the estimated model values to the measured resistance and reactance measured values.Results and discussionInitially, the use of InOr and FrOr models increased our understanding of the WRA physiopathology, showing increased peripheral resistance, damping, and hysteresivity. The FrOr model (AUC = 0.970) outperformed standard FO (AUC = 0.929), as well as InOr modeling (AUC = 0.838) in the diagnosis of respiratory changes, achieving high accuracy. FrOr improved the curve fitting (MSEt = 0.156 ± 0.340;Rd = 3.026 ± 1.072) in comparison with the InOr model (MSEt = 0.367 ± 0.991;Rd = 3.363 ± 1.098). Finally, we demonstrated that bronchodilator use increased dynamic compliance, as well as reduced damping and peripheral resistance.ConclusionsTaken together, these results show clear evidence of the utility of FO associated with fractional-order modeling in patients with WRA, improving our knowledge of the biomechanical abnormalities and the diagnostic accuracy in this disease. |
| Databáze: | OpenAIRE |
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