Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex

Autor: David Brang, Sofia Kakaizada, Saritha Krishna, Claudia Valdivia, Jacob S. Young, Christina Weyer-Jamora, Shawn L. Hervey-Jumper, Olivia Wiese, Mitchel S. Berger, Daniel H. Weissman, Jasleen Kaur, Alexander A Aabedi
Rok vydání: 2021
Předmět:
Male
Computer science
computer.software_genre
Lexicon
0302 clinical medicine
Voxel
2.1 Biological and endogenous factors
Longitudinal Studies
Prospective Studies
Aetiology
Brain Mapping
Language Tests
Multidisciplinary
Brain Neoplasms
Rehabilitation
05 social sciences
Cognition
Glioma
Middle Aged
Magnetic Resonance Imaging
Semantics
Neurology
Neurological
Medicine
Female
medicine.symptom
Comprehension
Natural language processing
Word (computer architecture)
Adult
Science
Prefrontal Cortex
Basic Behavioral and Social Science
Article
050105 experimental psychology
03 medical and health sciences
Text mining
Clinical Research
Aphasia
Behavioral and Social Science
medicine
Humans
Speech
0501 psychology and cognitive sciences
Cognitive rehabilitation therapy
Aged
business.industry
Neurosciences
Cognitive neuroscience
Brain Disorders
Support vector machine
Reading
Computational neuroscience
Case-Control Studies
Diseases of the nervous system
Artificial intelligence
business
computer
030217 neurology & neurosurgery
Neuroscience
Zdroj: Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
ISSN: 2045-2322
Popis: Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent and divergent results emerged. The presence of a single construct for auditory and visual processes of lexical retrieval would influence cognitive rehabilitation strategies for patients with aphasia. In this study, we perform support vector regression lesion-symptom mapping using a brain tumor model to test the hypothesis that brain regions specifically involved in lexical retrieval from visual and auditory stimuli represent overlapping neural systems. We find that principal components analysis of language tasks revealed multicollinearity between picture naming, auditory naming, and a validated measure of word finding, implying the existence of redundant cognitive constructs. Nonparametric, multivariate lesion-symptom mapping across participants was used to model accuracies on each of the four language tasks. Lesions within overlapping clusters of 8,333 voxels and 21,512 voxels in the left lateral prefrontal cortex (PFC) were predictive of impaired picture naming and auditory naming, respectively. These data indicate a convergence of heteromodal lexical retrieval within the PFC.
Databáze: OpenAIRE
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