A rare case of eosinophilic gastritis induced by nivolumab therapy for metastatic melanoma

Autor: Arisa Tsuji, Katsushi Hiramatsu, Shouichi Namikawa, Arisa Yamamoto, Yohei Midori, Yosuke Murata, Tomoko Tanaka, Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Yoshiaki Imamura, Shiro Iino, Minoru Hasegawa, Yasunari Nakamoto
Rok vydání: 2022
Předmět:
Zdroj: Clinical Journal of Gastroenterology. 15:876-880
ISSN: 1865-7265
1865-7257
Popis: Cancer immunotherapy using immune checkpoint inhibitors can cause immune reactions at various sites as a side effect called immune-related adverse events (irAEs). The gastrointestinal tract is susceptible to irAEs, however, the degree and presentation vary considerably from case to case. A 76-year-old woman was diagnosed with anal mucosal melanoma. She underwent radical surgery and received postoperative adjuvant therapy. However, because new metastases were also found in bilateral inguinal lymph nodes, immunotherapy with nivolumab was performed. Approximately 10 months after the initiation of nivolumab administration, she presented with epigastric discomfort and nausea, and her laboratory data showed severe eosinophilia (1938/mm
Databáze: OpenAIRE
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