Increased efficacy of a dendritic cell–based therapeutic cancer vaccine with adenosine receptor antagonist and CD73 inhibitor
| Autor: | Neda Mousavi Niri, Maryam Ajami, Mohammad Hossein Ghahremani, Mahbubeh Ashurpoor, Aida Safvati, Nasim Kheshtchin, Reza Mirzaei, Samaneh Arab, Jamshid Hadjati, Farhad Jadidi-Niaragh, Afshin Namdar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Receptor
Adenosine A2A medicine.medical_treatment Cell- and Tissue-Based Therapy Breast Neoplasms Pharmacology GPI-Linked Proteins Adenosine receptor antagonist Cancer Vaccines Mice 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Cell Line Tumor Tumor Microenvironment medicine Animals Humans 5'-Nucleotidase RC254-282 Tumor microenvironment business.industry Antibodies Monoclonal Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Dendritic Cells Neoplasms Experimental General Medicine Immunotherapy Dendritic cell medicine.disease Immunity Innate Purinergic P1 Receptor Antagonists 030220 oncology & carcinogenesis Female Cancer vaccine business 030215 immunology |
| Zdroj: | Tumor Biology, Vol 39 (2017) |
| ISSN: | 1423-0380 |
| Popis: | Dendritic cells are important in initiating immune responses; therefore, a range of dendritic cell–based approaches have been established to induce immune response against cancer cells. However, the presence of immunosuppressive mediators such as adenosine in the tumor microenvironment reduces the efficacy of dendritic cell–based cancer immunotherapy. In this study, we investigated whether blockade of the A2A adenosine receptor with a selective antagonist and a CD73 inhibitor may increase the efficacy of a dendritic cell–based cancer vaccine. According to the findings, this therapeutic combination reduced tumor growth, prolonged survival of tumor-bearing mice, and enhanced specific antitumor immune responses. Thus, we suggest that targeting cancer-derived adenosine improves the outcomes of dendritic cell–based cancer immunotherapy. |
| Databáze: | OpenAIRE |
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