Investigations into the Toxicology of Spirolides, a Group of Marine Phycotoxins
| Autor: | Shawna L. MacKinnon, Sandra Sperker, Rex Munday, Pamela Gallant, Patricia LeBlanc, Michael A. Quilliam, H. Stephen Ewart, Nancy I. Lewis |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Health
Toxicology and Mutagenesis In vitro cytotoxicity lcsh:Medicine Biology Pharmacology acute toxicity seafood poisoning Toxicology medicine.disease_cause Body weight Median lethal dose Risk Assessment Article Cell Line Lethal Dose 50 Mice medicine Animals Humans Spiro Compounds Cytotoxicity Toxin lcsh:R Alexandrium ostenfeldii spirolides Acute toxicity Female Marine Toxins Marine toxin marine phycotoxin |
| Zdroj: | Toxins Toxins; Volume 4; Issue 1; Pages: 1-14 Toxins, Vol 4, Iss 1, Pp 1-14 (2011) |
| ISSN: | 2072-6651 |
| Popis: | Spirolides are marine phycotoxins produced by the dinoflagellates Alexandrium ostenfeldii and A. peruvianum. Here we report that 13-desmethyl spirolide C shows little cytotoxicity when incubated with various cultured mammalian cell lines. When administered to mice by intraperitoneal (ip) injection, however, this substance was highly toxic, with an LD(50) value of 6.9 µg/kg body weight (BW), showing that such in vitro cytotoxicity tests are not appropriate for predicting the in vivo toxicity of this toxin. Four other spirolides, A, B, C, and 20-methyl spirolide G, were also toxic to mice by ip injection, with LD(50) values of 37, 99, 8.0 and 8.0 µg/kg BW respectively. However, the acute toxicities of these compounds were lower by at least an order of magnitude when administration by gavage and their toxic effects were further diminished when administered with food. These results have implications for future studies of the toxicology of these marine toxins and the risk assessment of human exposure. |
| Databáze: | OpenAIRE |
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