Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy
| Autor: | K.M. Dolman, A.E.G.Kr. von dem Borne, R. Goldschmeding, R.D.B. Gans, AjM Donker, Th.J. Vervaat, G. Zevenbergen, D. Maingay, R.E. Nikkels |
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| Přispěvatelé: | Lifelong Learning, Education & Assessment Research Network (LEARN), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Other departments |
| Rok vydání: | 1993 |
| Předmět: |
Adult
Vasculitis endocrine system Antineutrophil Cytoplasmic Hyperthyroidism/drug therapy Propylthiouracil/adverse effects Hyperthyroidism Antibodies Antibodies Antineutrophil Cytoplasmic Proteinase 3 immune system diseases Immunopathology medicine Humans cardiovascular diseases Vasculitis/chemically induced skin and connective tissue diseases Immunoglobulin G/immunology Anti-neutrophil cytoplasmic antibody Aged Autoantibodies biology business.industry Elastase Autoantibody General Medicine Middle Aged medicine.disease respiratory tract diseases Propylthiouracil Myeloperoxidase Immunoglobulin G Immunology biology.protein Female business Autoantibodies/immunology Biomarkers medicine.drug |
| Zdroj: | The Lancet, 342(8872), 651-652. ELSEVIER SCIENCE INC Lancet, 342(8872), 651-652. Elsevier Limited |
| ISSN: | 0140-6736 |
| Popis: | Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely. |
| Databáze: | OpenAIRE |
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