Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies
| Autor: | Rino Ragno, Anna Minarini, Eleonora Proia, Antonini Lorenzo, Andrea Milelli, Vincenzo Tumiatti, Marco Fiore, Pasquale Fino, Lavinia Rutigliano, Rossella Fioravanti, Tomoaki Tahara, Elena Pacella, Antonio Greco, Gianluca Canettieri, Maria Luisa Di Paolo, Enzo Agostinelli |
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| Rok vydání: | 2022 |
| Předmět: |
bovine serum amine oxidase
chemical synthesis biological evaluation molecular docking 3-D QSAR General Chemical Engineering Quantitative Structure-Activity Relationship Antineoplastic Agents General Chemistry Library and Information Sciences Ligands Molecular Docking Simulation Monoamine Oxidase Polyamines Spermine Computer Science Applications |
| Zdroj: | Journal of Chemical Information and Modeling. 62:3910-3927 |
| ISSN: | 1549-960X 1549-9596 |
| DOI: | 10.1021/acs.jcim.2c00559 |
| Popis: | Natural polyamines (PAs) are key players in cellular homeostasis by regulating cell growth and proliferation. Several observations highlight that PAs are also implicated in pathways regulating cell death. Indeed, the PA accumulation cytotoxic effect, maximized with the use of bovine serum amine oxidase (BSAO) enzyme, represents a valuable strategy against tumor progression. In the present study, along with the design, synthesis, and biological evaluation of a series of new spermine (Spm) analogues ( |
| Databáze: | OpenAIRE |
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