Efficacy and Safety of Endoscopic Nasopharyngectomy Combined With Low-Dose Radiotherapy for Primary T1-2 Nasopharyngeal Carcinoma
| Autor: | Jingjin Weng, Yongfeng Si, Benjian Zhang, Guiping Lan, Shenhong Qu, Yu Lu, Bo Huang, Jianhui Luo, Yiliang Li, Molu Ban |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_treatment 0302 clinical medicine Pharyngectomy Quality of life Nasopharynx endoscopic nasopharyngectomy Endoscopic nasopharyngectomy Low dose radiotherapy RC254-282 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Radiotherapy Dosage Middle Aged intensity-modulated radiotherapy Combined Modality Therapy Survival Rate Oncology 030220 oncology & carcinogenesis Original Article Female Radiology Intensity modulated radiotherapy Adult medicine.medical_specialty Xerostomia 03 medical and health sciences medicine otorhinolaryngologic diseases Humans Hearing Loss Neoplasm Staging Retrospective Studies business.industry nasopharyngeal carcinoma Carcinoma Endoscopy Nasopharyngeal Neoplasms medicine.disease Radiation therapy 030104 developmental biology quality of life Nasopharyngeal carcinoma Radiotherapy Intensity-Modulated low-dose radiotherapy Neoplasm Recurrence Local Deglutition Disorders business Follow-Up Studies |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 20 (2021) Technology in Cancer Research & Treatment |
| ISSN: | 1533-0338 |
| Popis: | Aim: Intensity-modulated radiotherapy (IMRT) is a widely accepted therapy for nasopharyngeal carcinoma (NPC), but it inevitably brings out radiation-related complications and seriously affects the quality of life (QoL). Endoscopic nasopharyngectomy (ENPG) has been successfully conducted in locally recurred NPC, but few studies evaluated its application in early NPC. This study aims to assess the feasibility and safety of ENPG combined with low-dose radiotherapy (LDRT) in T1-2 NPC. Patients and Methods: We recruited 37 newly diagnosed localized T1-2 NPC patients who voluntarily accepted ENPG +LDRT from June 2013 to September 2016. Meanwhile, the data of 132 T1-2 NPC patients treated with IMRT were collected and used as control group. The survival outcomes, QoL score and late RT-related sequelaes were compared between the 2 groups. Results: After a median follow-up of 54 months, only 1 patient in ENPG+LDRT group died along with hepatic metastases. The 5-year overall survival, distant metastasis-free survival, local relapse-free survival and regional relapse-free survival in ENPG+LDRT group were 97.3%, 97.3%, 100% and 100%, which were not statistically different from the control group (97.7%, 90.2%, 95. 5%, 97.0%, respectively, all P > 0.05). In comparison with IMRT group, ENPG+LDRT exhibited better QoL and less rate of late RT-related sequlaes including hearing loss (53.8% vs 27.0%, P = 0.005), xerostomia (46.2% vs 24.3%, P = 0.023) and dysphagia (25.8% vs 8.1%, P = 0.024). Conclusions: ENPG+LDRT provided satisfactory survival outcomes, and improved the QoL and reduced the incidence of sequelae for T1-2 NPC patients. |
| Databáze: | OpenAIRE |
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