The mitochondrial activity of leukocytes from Artibeus jamaicensis bats remains unaltered after several weeks of flying restriction
| Autor: | Simon Kolstoe, F. Javier Sánchez-García, C. Angélica Pérez-Hernández, Alun R. Coker, José Alvaro Aguilar-Setien, María Maximina Bertha Moreno-Altamirano, Emilio Rendón-Franco |
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| Rok vydání: | 2021 |
| Předmět: |
Mitochondrial ROS
medicine.medical_specialty Glucose uptake Immunology Longevity Captivity Oxidative phosphorylation Mitochondrion Superoxide dismutase Internal medicine Chiroptera medicine Leukocytes Animals Artibeus chemistry.chemical_classification Mammals Reactive oxygen species biology fungi biology.organism_classification Mitochondria Endocrinology chemistry biology.protein Developmental Biology |
| Zdroj: | Developmental and comparative immunology. 127 |
| ISSN: | 1879-0089 |
| Popis: | Bats are the only flying mammals known. They have longer lifespan than other mammals of similar size and weight and can resist high loads of many pathogens, mostly viruses, with no signs of disease. These distinctive characteristics have been attributed to their metabolic rate that is thought to be the result of their flying lifestyle. Compared with non-flying mammals, bats have lower production of reactive oxygen species (ROS), and high levels of antioxidant enzymes such as superoxide dismutase. This anti-oxidative vs. oxidative profile may help to explain bat's longer than expected lifespans. The aim of this study was to assess the effect that a significant reduction in flying has on bats leukocytes mitochondrial activity. This was assessed using samples of lymphoid and myeloid cells from peripheral blood from Artibeus jamaicensis bats shortly after capture and up to six weeks after flying deprivation. Mitochondrial membrane potential (Δψm), mitochondrial calcium (mCa2+), and mitochondrial ROS (mROS) were used as key indicators of mitochondrial activity, while total ROS and glucose uptake were used as additional indicators of cell metabolism. Results showed that total ROS and glucose uptake were statistically significantly lower at six weeks of flying deprivation (p 0.05). These results suggest that bat mitochondria are stable to sudden changes in physical activity, at least up to six weeks of flying deprivation. However, decrease in total ROS and glucose uptake in myeloid cells after six weeks of captivity suggest a compensatory mechanism due to the lack of the highly metabolic demands associated with flying. |
| Databáze: | OpenAIRE |
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