Pulmonary vascular resistance in adult rats exposed to hypoxia in the neonatal period
| Autor: | J. P. Mortola, Tawfic S. Hakim |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Pulmonary Circulation Physiology Hemodynamics Blood Pressure Hematocrit Biology Physiology (medical) medicine Animals Hypoxia Lung Pharmacology medicine.diagnostic_test Angiotensin II Rats Inbred Strains General Medicine Hypoxia (medical) Rats medicine.anatomical_structure Blood pressure Animals Newborn Anesthesia Circulatory system Vascular resistance Female Vascular Resistance medicine.symptom Blood vessel |
| Zdroj: | Canadian journal of physiology and pharmacology. 68(3) |
| ISSN: | 0008-4212 |
| Popis: | Newborn rats were exposed to hypoxia (10% O2 + N2) from 24 h to day 6 of neonatal life and then returned to room air until 45 days of age (experimental). The rats were anaesthetized, heparinized, and exsanguinated. The chest was opened and the lungs were perfused with diluted autologous blood at a constant flow rate (Q). The pulmonary arterial pressure (Pa) and venous pressure (Pv) were monitored. The properties of the pulmonary vasculature were assessed by measuring baseline vascular resistance, PVR = (Pa−Pv)/Q, segmental pressure gradients (double occlusion technique), pressure–flow relationship, hypoxic pressor response (HPR, 3% O2), and the response to 0.5 μg bolus of angiotensin II (AII). These were compared with similar measurements on age-matched control animals never exposed to hypoxia. The perfusate hematocrit and gases were not significantly different between the two groups. The PVR normalized to body weight was 30% higher in the experimental groups (p |
| Databáze: | OpenAIRE |
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