Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla
| Autor: | Yue Wang, Qing-Lan Guo, Cheng-Bo Xu, Jiangong Shi, Cheng-Gen Zhu, Ruo-Fei Li |
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| Rok vydání: | 2019 |
| Předmět: |
China
Circular dichroism Magnetic Resonance Spectroscopy Stereochemistry Decoction 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Hydrolysis Folic Acid 0302 clinical medicine Drug Discovery Derivatization Chromatography High Pressure Liquid Aqueous solution Molecular Structure Plant Stems biology Plant Extracts 010405 organic chemistry Uncaria rhynchophylla General Medicine biology.organism_classification 0104 chemical sciences Uncaria Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Specific rotation Cotton effect |
| Zdroj: | Chinese Journal of Natural Medicines. 17:928-934 |
| ISSN: | 1875-5364 |
| Popis: | Two new folate-derived analogues, named uncarophyllofolic acids A (1) and B (2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem (Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey's derivatization, along with comparison of their specific rotation and Cotton effect (CE) data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway of 1 and 2, associating to folate metabolism and the previously reported orychophragines A-C from Orychophragmus violaceus, is discussed. |
| Databáze: | OpenAIRE |
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