METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis
Autor: | Shuo Liu, Nicholas D. Nguyen, John A. Porco, Laura Hulea, Marcello Caporicci, Jiuwei Lu, Jikui Song, Ami Li, Or Gozani, Shane Lofgren, Simone Hausmann, Michael Paul Kim, Pawel K. Mazur, Anirban Maitra, Capucine Van Rechem, Michael C. Bassik, Huamin Wang, Kristofferson Tandoc, Renjitha Pillai, Ivan Topisirovic, Mary Esmeralda Fuentes, Ignacio I. Wistuba, Joshua E. Elias, Joel William Francis, Scott M. Carlson |
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Rok vydání: | 2019 |
Předmět: |
Proteomics
Male Carcinogenesis pancreatic cancer translation Inbred C57BL Cell Transformation Medical and Health Sciences Transgenic Mice 0302 clinical medicine Peptide Elongation Factor 1 Translation elongation Biological sciences Lung Cancer Mice Knockout 0303 health sciences Lung Cancer Biological Sciences Mice transgenic lysine methylation Cell Transformation Neoplastic Heterografts Female Signal Transduction Adult Knockout Library science Mice Transgenic Biology Methylation General Biochemistry Genetics and Molecular Biology Article Cell Line eEF1A 03 medical and health sciences Rare Diseases Animals Humans protein methylation Protein Processing 030304 developmental biology Aged Neoplastic Lysine Post-Translational Methyltransferases translation elongation Mice Inbred C57BL Pancreatic Neoplasms HEK293 Cells Protein Biosynthesis METTL13 Digestive Diseases Protein Processing Post-Translational 030217 neurology & neurosurgery RAS Developmental Biology |
Zdroj: | Cell, vol 176, iss 3 |
Popis: | We thank Pal Falnes, Jerry Pelletier, and Julien Sage for helpful discussion, Lauren Brown and William Devine for SDS-1-021, and members of the Gozani and Mazur laboratories for critical reading of the manuscript. This work was supported in part by grants from the NIH to S.M.C. (K99CA190803), M.P.K. (5K08CA218690-02), J.A.P. (R35GM118173), M.C.B. (1DP2HD084069-01), J.S. (1R35GM119721), I.T. (R01CA202021), P.K.M. (R00CA197816, P50CA070907, and P30CA016672), and O.G. (R01GM079641). J.E.E. received support from Stanford ChEM-H, and A.M. was supported by the MD Anderson Moonshot Program. I.T. is a Junior 2 Research Scholar of the Fonds de Recherche du Quebec - Sante (FRQ-S). P.K.M. is supported by the Neuroendocrine Tumor Research Foundation and American Association for Cancer Research and is the Andrew Sabin Family Foundation Scientist and CPRIT scholar (RR160078). S.H. is supported by a Deutsche Forschungsgemeinschaft Postdoctoral Fellowship. J.W.F. is supported by 5T32GM007276. (K99CA190803 - NIH; 5K08CA218690-02 - NIH; R35GM118173 - NIH; 1DP2HD084069-01 - NIH; 1R35GM119721 - NIH; R01CA202021 - NIH; R00CA197816 - NIH; P50CA070907 - NIH; P30CA016672 - NIH; R01GM079641 - NIH; Stanford ChEM-H; MD Anderson Moonshot Program; Neuroendocrine Tumor Research Foundation; American Association for Cancer Research; Deutsche Forschungsgemeinschaft Postdoctoral Fellowship; 5T32GM007276) |
Databáze: | OpenAIRE |
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