METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis

Autor: Shuo Liu, Nicholas D. Nguyen, John A. Porco, Laura Hulea, Marcello Caporicci, Jiuwei Lu, Jikui Song, Ami Li, Or Gozani, Shane Lofgren, Simone Hausmann, Michael Paul Kim, Pawel K. Mazur, Anirban Maitra, Capucine Van Rechem, Michael C. Bassik, Huamin Wang, Kristofferson Tandoc, Renjitha Pillai, Ivan Topisirovic, Mary Esmeralda Fuentes, Ignacio I. Wistuba, Joshua E. Elias, Joel William Francis, Scott M. Carlson
Rok vydání: 2019
Předmět:
Proteomics
Male
Carcinogenesis
pancreatic cancer
translation
Inbred C57BL
Cell Transformation
Medical and Health Sciences
Transgenic
Mice
0302 clinical medicine
Peptide Elongation Factor 1
Translation elongation
Biological sciences
Lung
Cancer
Mice
Knockout

0303 health sciences
Lung Cancer
Biological Sciences
Mice transgenic
lysine methylation
Cell Transformation
Neoplastic

Heterografts
Female
Signal Transduction
Adult
Knockout
Library science
Mice
Transgenic

Biology
Methylation
General Biochemistry
Genetics and Molecular Biology

Article
Cell Line
eEF1A
03 medical and health sciences
Rare Diseases
Animals
Humans
protein methylation
Protein Processing
030304 developmental biology
Aged
Neoplastic
Lysine
Post-Translational
Methyltransferases
translation elongation
Mice
Inbred C57BL

Pancreatic Neoplasms
HEK293 Cells
Protein Biosynthesis
METTL13
Digestive Diseases
Protein Processing
Post-Translational

030217 neurology & neurosurgery
RAS
Developmental Biology
Zdroj: Cell, vol 176, iss 3
Popis: We thank Pal Falnes, Jerry Pelletier, and Julien Sage for helpful discussion, Lauren Brown and William Devine for SDS-1-021, and members of the Gozani and Mazur laboratories for critical reading of the manuscript. This work was supported in part by grants from the NIH to S.M.C. (K99CA190803), M.P.K. (5K08CA218690-02), J.A.P. (R35GM118173), M.C.B. (1DP2HD084069-01), J.S. (1R35GM119721), I.T. (R01CA202021), P.K.M. (R00CA197816, P50CA070907, and P30CA016672), and O.G. (R01GM079641). J.E.E. received support from Stanford ChEM-H, and A.M. was supported by the MD Anderson Moonshot Program. I.T. is a Junior 2 Research Scholar of the Fonds de Recherche du Quebec - Sante (FRQ-S). P.K.M. is supported by the Neuroendocrine Tumor Research Foundation and American Association for Cancer Research and is the Andrew Sabin Family Foundation Scientist and CPRIT scholar (RR160078). S.H. is supported by a Deutsche Forschungsgemeinschaft Postdoctoral Fellowship. J.W.F. is supported by 5T32GM007276. (K99CA190803 - NIH; 5K08CA218690-02 - NIH; R35GM118173 - NIH; 1DP2HD084069-01 - NIH; 1R35GM119721 - NIH; R01CA202021 - NIH; R00CA197816 - NIH; P50CA070907 - NIH; P30CA016672 - NIH; R01GM079641 - NIH; Stanford ChEM-H; MD Anderson Moonshot Program; Neuroendocrine Tumor Research Foundation; American Association for Cancer Research; Deutsche Forschungsgemeinschaft Postdoctoral Fellowship; 5T32GM007276)
Databáze: OpenAIRE