Intracortical microstimulation differentially activates cortical layers based on stimulation depth
| Autor: | Peter Hubka, Mathias Benjamin Voigt, Andrej Kral |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Neuroprosthetic Neuroprosthetics Guinea Pigs Population Biophysics Stimulation Local field potential Auditory cortex lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Hearing Animals education lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Auditory Cortex education.field_of_study Chemistry General Neuroscience Electric Stimulation 030104 developmental biology Intracortical microstimulation Acoustic Stimulation Cortical response Cortical implants Evoked Potentials Auditory Cortical implant Neurology (clinical) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Stimulation, Vol 10, Iss 3, Pp 684-694 (2017) |
| ISSN: | 1935-861X |
| DOI: | 10.1016/j.brs.2017.02.009 |
| Popis: | Background: Intracortical microstimulation is one of the most common techniques to causally interfere with neuronal processing, but neuronal recordings spanning the whole cortical depth during stimulation are exceptionally rare. Objective/Hypothesis: Here we combined layer-specific intracortical microstimulation with extracellular recordings on the same shank of a linear multi-electrode array to study the effects of electrical stimulation in different cortical depths on intracortical processing in the auditory cortex in vivo. Methods: Population responses (local field potentials and multi-unit activity) were recorded from the auditory cortex of 8 guinea pigs under ketamine/xylazine anesthesia while single current pulses (charge-balanced, biphasic, square-wave, 0.1–45 μA, 200 μs/phase) were delivered in different cortical depths. Results: The cortical responses differed with a change in the stimulation parameters, with significant factors being the stimulating current (p |
| Databáze: | OpenAIRE |
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