Molecularly imprinted polymer doped with Hectorite for selective recognition of sinomenine hydrochloride
| Autor: | Wen Zhang, Wei Li, Xianhui Li, Ning Wang, Xing Xiang Zhang, Hua Zhang, H L Fu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Langmuir
Materials science Ethylene glycol dimethacrylate Biomedical Engineering Biophysics Bioengineering 02 engineering and technology 01 natural sciences Polymerization Molecular Imprinting Biomaterials chemistry.chemical_compound Polymethacrylic Acids Polymer chemistry Freundlich equation Drug Carriers Silicates 010401 analytical chemistry Molecularly imprinted polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation Kinetics Morphinans Methacrylic acid chemistry Precipitation polymerization Hectorite Adsorption 0210 nano-technology Molecular imprinting Nuclear chemistry |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 27:144-156 |
| ISSN: | 1568-5624 0920-5063 |
| Popis: | In this work, a new and facile method was introduced to prepare molecularly imprinted polymers (MIPs) based on nano clay hectorite (Hec) for sinomenine hydrochloride (SM) analysis. Hec was firstly dissolved in distilled water in order to swell adequately, followed by a common precipitation polymerization with SM as the template, methacrylic acid as monomer, ethylene glycol dimethacrylate as a crosslinker and 2,2-azobisisobutyronitrile as an initiator. Hec@SM-MIPs were characterized by Fourier transform infrared spectrometer, transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction. The maximum binding capacity of Hec@SM-MIPs, SM-MIPs and non-imprinted polymers (NIPs) (Hec@NIPs) was 57.4, 16.8 and 11.6 mg/g, respectively. The reason for this result may be that Hec@SM-MIPs have more binding sites and imprinted cavities for template molecule. Equilibrium data were described by the Langmuir and Freundlich isotherm models. The results showed that the Hec@SM-MIPs adsorption data correlated better with the Langmuir equation than the Freundlich equation under the studied concentration range. In vitro drug release experiment, Hec@SM-MIPs have a better ability to control SM release than SM-MIPs. Therefore, Hec@SM-MIPs were successfully applied to extraction of SM and used as the materials for drug delivery system. |
| Databáze: | OpenAIRE |
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