Hypergonadotrophic hypogonadism due to testicular adrenal rest tumours presenting with hypogonadotrophic hypergonadism
| Autor: | Hariom Sur, Rouvick M Gama, Clare Ford, Helen L Ashby, Rousseau Gama, John A Inglis |
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| Rok vydání: | 2012 |
| Předmět: |
Infertility
Adult Male endocrine system medicine.medical_specialty Adrenal Rest Tumor endocrine system diseases Clinical Biochemistry urologic and male genital diseases Congenital Abnormalities Follicle-stimulating hormone Internal medicine medicine Humans Congenital adrenal hyperplasia Testosterone Glucocorticoids Azoospermia Hypergonadism urogenital system business.industry Hypogonadism General Medicine Luteinizing Hormone medicine.disease female genital diseases and pregnancy complications Semen Analysis Endocrinology Follicle Stimulating Hormone business Luteinizing hormone |
| Zdroj: | Annals of clinical biochemistry. 49(Pt 5) |
| ISSN: | 1758-1001 |
| Popis: | Primary testicular failure is characterized by low serum testosterone with appropriately high serum gonadotrophins, that is hypergonadotrophic hypogonadism. We report on a 27-year-old man with congenital adrenal hyperplasia (CAH) and infertility due to testicular adrenal rest rumours (TART) resulting in primary testicular failure but presenting with azoospermia, elevated serum testosterone and very low serum gonadotrophins. Hypergonadotrophic hypogonadism was unmasked by increasing glucocorticoid dosage. It is important to recognise the limitations of follicle-stimulating hormone, luteinising hormone and testosterone in assessing testicular function in men with CAH. Abnormal semen analysis may be the best indicator of testicular dysfunction in men with CAH. |
| Databáze: | OpenAIRE |
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