The treatment of a hyperandrogenic and virilizing state in an elderly female with a synthetic LHRH agonist
| Autor: | M. Seed, V. Wynn, J. H. Parr, F. Short, R. R. Abraham |
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| Rok vydání: | 1988 |
| Předmět: |
Agonist
endocrine system medicine.medical_specialty Hydrocortisone medicine.drug_class Endocrinology Diabetes and Metabolism Ethinyl Estradiol Antiandrogen Gonadotropin-Releasing Hormone chemistry.chemical_compound Endocrinology Internal medicine Humans Medicine Testosterone Cyproterone Cyproterone Acetate Aged Aged 80 and over Triptorelin Pamoate business.industry Virilization Hyperthecosis Hyperandrogenism Cyproterone acetate medicine.disease Virilism chemistry Estrogen Drug Therapy Combination Female medicine.symptom business Gonadotropins hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Endocrinological Investigation. 11:433-436 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03349077 |
| Popis: | A case of hyperandrogenism and virilization is described in an elderly female. She had elevated testosterone levels, but normal DHEAS and 24-h urinary 17-oxosteroid excretion, suggesting an ovarian tumor. Stimulation and suppression tests, and radioisotopic and radiological scans proved unhelpful in the diagnosis although hyperthecosis of the ovary was later suggested by ultrasound. Testosterone and gonadotropin levels fell during therapy with cyproterone acetate and subsequently ethinyl estradiol. Because of side effects encountered on these drugs, she was treated with a synthetic, slow-release preparation of an LHRH agonist, D-TRP-6-LHRH (Decapeptyl), with symptomatic and biochemical improvement. Long term LHRH agonists might be a valuable treatment for hyperandrogenic states in elderly patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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