Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjögren’s syndrome: a comparative study
| Autor: | Luciana Yamamoto Almeida, Fernanda Carolina Jacomini, Karen Cristine Bortoletto, Evânio Vilela Silva, Eduardo Rocha, Bruno Augusto Benevenuto de Andrade, Alfredo Ribeiro-Silva, Roman Carlos, Jorge Esquiche León, Flávio Calil Petean, Andressa Duarte, Isabela Barbosa Quero, Heitor Albergoni Da Silveira |
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| Přispěvatelé: | Universidade Estadual Paulista (UNESP), Universidade de São Paulo (USP), Universidade Federal do Rio de Janeiro (UFRJ), Hospital Herrera-Llerandi/AMEDESGUA |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Biopsy Immunology Gastroenterology Asymptomatic Sialadenitis Ectopic germinal centers stomatognathic system Rheumatology Focal lymphocytic sialadenitis Internal medicine medicine Humans Immunology and Allergy Lymphocytes Non-Sjögren’s non-sicca patient Salivary gland business.industry Chronic sclerosing sialadenitis CD23 Germinal center Germinal Center medicine.disease Immunohistochemistry eye diseases Oral reactive lesions stomatognathic diseases Sjogren's Syndrome medicine.anatomical_structure Sjögren’s syndrome medicine.symptom business |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2022-04-29T08:30:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Focal lymphocytic sialadenitis (FLS), an important diagnostic criterion for Sjögren’s syndrome (SS) diagnosis, can also be observed when assessing minor salivary gland (mSG) biopsies from healthy asymptomatic individuals (non-SS patients). Fifty cases of primary SS (pSS group) and 31 cases of oral reactive lesions (non-SS non-sicca group) containing also typical FLS features, were assessed by morphological and immunohistochemical (CD10, CD23 and Bcl-6) analysis, aiming at the detection of GCs. All pSS cases showed FLS with focus score (FS) ≥ 1. In the non-SS non-sicca group, 12, 10 and 9 cases showed FLS with FS ≥ 1, FLS with FS < 1 and FLS associated with chronic sclerosing sialadenitis with FS < 1, respectively. The morphological analysis revealed similar frequency of GCs in pSS (20%) and non-SS non-sicca group (19%). The area (p = 0.052) and largest diameter (p = 0.245) of GCs were higher in pSS than non-SS non-sicca group. The FS and number of foci were significantly higher in pSS than non-SS non-sicca group with FS < 1. Immunohistochemistry confirmed all morphological findings (GCs showing CD23 and Bcl-6 positivity, with variable CD10 expression) and additionally in 3 and 1 cases of the pSS and non-SS non-sicca group, respectively. Moreover, another 6 and 2 cases of the pSS and non-SS non-sicca group with FS ≥ 1, respectively, showed positivity only for CD23. FLS can also be observed when assessing oral reactive lesions, which showed similar frequency of GCs with those found in pSS patients. Further studies, including functional analysis of lymphocytic populations and GCs in FLS, are encouraged. Oral Medicine Department of Diagnosis and Surgery Araraquara Dental School Sao Paulo State University (UNESP) Oral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry School of Dentistry of Ribeirão Preto University of São Paulo (FORP/USP) Oral Pathology Department of Oral Diagnosis and Pathology School of Dentistry Federal University of Rio de Janeiro (UFRJ) Department of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São Paulo Department of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo Departament of Pathology Hospital Herrera-Llerandi/AMEDESGUA Oral Medicine Department of Diagnosis and Surgery Araraquara Dental School Sao Paulo State University (UNESP) |
| Databáze: | OpenAIRE |
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