Cerebrospinal fluid HIV viral load in different phases of HIV–associated brain disease
| Autor: | H.-J. Von Giesen, Hubertus Köller, Gabriele Arendt, Ortwin Adams |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Time Factors Movement HIV Infections Asymptomatic Fingers Central nervous system disease Cerebrospinal fluid Acquired immunodeficiency syndrome (AIDS) Immunopathology medicine Humans Dementia Brain Diseases business.industry HIV Middle Aged Viral Load medicine.disease Neurology Immunology RNA Viral Regression Analysis Female Neurology (clinical) Viral disease medicine.symptom business Viral load |
| Zdroj: | Journal of Neurology. 252:801-807 |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | We compared CSF HIV viral load in 33 asymptomatic HIV seropositive patients, 11 patients with incipient minor motor deficits (MMD), 11 patients with sustained MMD, and 16 patients with HIV-associated dementia. Patients with incipient MMD showed significantly higher CSF viral load than asymptomatic patients. Demented patients also had higher CSF viral loads than asymptomatic patients. This phenomenon is independent of antiretroviral therapy. Thus, correlation of viral load with time suggests a multiphasic course of HIV-associated CNS disease. |
| Databáze: | OpenAIRE |
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