Impact of hepatobiliary service centralization on treatment and outcomes in patients with colorectal cancer and liver metastases
| Autor: | Kate Walker, David G. Jayne, A Vallance, I D Botterill, J vanderMeulen, James Hill, Angela Kuryba |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Colorectal cancer medicine.medical_treatment Kaplan-Meier Estimate 030230 surgery Young Adult 03 medical and health sciences 0302 clinical medicine Oncology Service Hospital medicine Hepatectomy Humans Young adult Child Survival analysis Aged Proportional Hazards Models Aged 80 and over business.industry Proportional hazards model General surgery Liver Neoplasms Hazard ratio Infant Newborn Infant Original Articles Odds ratio Middle Aged medicine.disease Surgery Treatment Outcome Child Preschool 030220 oncology & carcinogenesis Centralized Hospital Services Female Original Article Colorectal Neoplasms business Cohort study |
| Zdroj: | The British Journal of Surgery |
| ISSN: | 1365-2168 0007-1323 |
| Popis: | Background Centralization of specialist surgical services can improve patient outcomes. The aim of this cohort study was to compare liver resection rates and survival in patients with primary colorectal cancer and synchronous metastases limited to the liver diagnosed at hepatobiliary surgical units (hubs) with those diagnosed at hospital Trusts without hepatobiliary services (spokes). Methods The study included patients from the National Bowel Cancer Audit diagnosed with primary colorectal cancer between 1 April 2010 and 31 March 2014 who underwent colorectal cancer resection in the English National Health Service. Patients were linked to Hospital Episode Statistics data to identify those with liver metastases and those who underwent liver resection. Multivariable random‐effects logistic regression was used to estimate the odds ratio of liver resection by presence of specialist hepatobiliary services on site. Survival curves were estimated using the Kaplan–Meier method. Results Of 4547 patients, 1956 (43·0 per cent) underwent liver resection. The 1081 patients diagnosed at hubs were more likely to undergo liver resection (adjusted odds ratio 1·52, 95 per cent c.i. 1·20 to 1·91). Patients diagnosed at hubs had better median survival (30·6 months compared with 25·3 months for spokes; adjusted hazard ratio 0·83, 0·75 to 0·91). There was no difference in survival between hubs and spokes when the analysis was restricted to patients who had liver resection (P = 0·620) or those who did not undergo liver resection (P = 0·749). Conclusion Patients with colorectal cancer and synchronous metastases limited to the liver who are diagnosed at hospital Trusts with a hepatobiliary team on site are more likely to undergo liver resection and have better survival. Better survival |
| Databáze: | OpenAIRE |
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