Overexpression of Fibrinogen in ApoE*3-Leiden Transgenic Mice Does not Influence the Progression of Diet-Induced Atherosclerosis
| Autor: | M. van der Linden, M. J. Gijbels, M.P.M. de Maat, Jan H. Verheijen, Farhad Rezaee, E.H. Offerman |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Thrombosis and haemostasis, 88(2), 329-334. Schattauer GmbH |
| ISSN: | 2567-689X 0340-6245 |
| Popis: | SummaryAlthough many epidemiological studies have shown an association between hyperfibrinogenemia and atherosclerosis, it is not established whether elevated fibrinogen has an etiological role in the pathogenesis or is only a reflection of the ongoing disease.We have studied the contribution of fibrinogen to the development of atherosclerosis in atherosclerosis-prone ApoE*3-Leiden mice that have been cross-bred with transgenic mice overexpressing fibrinogen. Genetic compound offspring were used to evaluate the progression of atherosclerotic lesions after being fed an atherogenic diet for 7 weeks. It was observed that the lesion area of the plaques as well as the severity of the lesions in the aortic valve was comparable in control single transgenic ApoE*3-Leiden mice and in double transgenic apoE*3-Leiden mice overexpressing fibrinogen. No thrombus or fibrin deposition was observed in atherosclerotic lesions in either group of mice.These results indicate that elevated plasma fibrinogen concentrations in ApoE*3-Leiden transgenic mice do not affect the progression of diet-induced atherosclerotic lesions. |
| Databáze: | OpenAIRE |
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