Non-Coding RNAs in Glioma
| Autor: | Ingrida Meskinyte, Ryte Rynkeviciene, Julija Simiene, Edita Miseikyte Kaubriene, Egle Strainiene, Jonas Cicenas, Vaidotas Stankevicius, Jurgita Usinskiene, Kestutis Suziedelis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research non-coding RNA Brain tumor Review Biology lcsh:RC254-282 Pathogenesis 03 medical and health sciences lncRNA Glioma glioma microRNA medicine neoplasms miRNA RNA lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Non-coding RNA Phenotype nervous system diseases Crosstalk (biology) 030104 developmental biology Oncology Cancer research |
| Zdroj: | Cancers, Vol 11, Iss 1, p 17 (2018) Cancers |
| Popis: | Glioma is the most aggressive brain tumor of the central nervous system. The ability of glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, and heterogeneity contribute to an overall survival of approximately 15 months for most patients with high grade glioma. Numerous studies indicate that non-coding RNA species have critical functions across biological processes that regulate glioma initiation and progression. Recently, new data emerged, which shows that the cross-regulation between long non-coding RNAs and small non-coding RNAs contribute to phenotypic diversity of glioblastoma subclasses. In this paper, we review data of long non-coding RNA expression, which was evaluated in human glioma tissue samples during a five-year period. Thus, this review summarizes the following: (I) the role of non-coding RNAs in glioblastoma pathogenesis, (II) the potential application of non-coding RNA species in glioma-grading, (III) crosstalk between lncRNAs and miRNAs (IV) future perspectives of non-coding RNAs as biomarkers for glioma. This work was funded by the Research Council of Lithuania, project MIP-015/2014 |
| Databáze: | OpenAIRE |
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