Hepatic artery infusion chemotherapy for colorectal metastases: A personal experience
| Autor: | William L. Donegan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty animal structures Colorectal cancer medicine.medical_treatment Rectum Gastroenterology Mitomycins Metastasis Hepatic Artery Postoperative Complications Hepatic arterial infusion Internal medicine medicine Humans Infusions Intra-Arterial Aged Chemotherapy Rectal Neoplasms business.industry Carcinoma Liver Neoplasms Mitomycin C virus diseases General Medicine Middle Aged medicine.disease Artery infusion medicine.anatomical_structure Oncology Fluorouracil Colonic Neoplasms Female Surgery Floxuridine business medicine.drug |
| Zdroj: | Journal of Surgical Oncology. 30:177-183 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.2930300311 |
| Popis: | A personal experience is reported with hepatic artery infusion (HAI) chemotherapy of 57 patients with metastatic colorectal carcinoma confined to the liver. Fifty-seven percent of the 54 patients who received more than 2 weeks of infusion had objective regressions documented on hepatic scans. The response rate with fluorouracil and mitomycin C (75%) was higher than for fluorouracil alone (52.5%). The median survival of treated patients was 15 months with the longest survivor living 3 years 8 months, and responders had a median survival 3 months longer than nonresponders. Complications included one case of hemolytic uremic syndrome after HAI with mitomycin C. Survival after HAI was 9 months longer than that of comparable historical controls who received no treatment, but survival after HAI with fluorouracil alone was not superior to that of comparable patients treated with intravenous fluorouracil. HAI produces a high frequency of tumor regression, but superior survival has yet to be demonstrated. |
| Databáze: | OpenAIRE |
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