Maternal Stress and Depressive Symptoms and Infant Development at Six Months: the Mothers and Children's Environmental Health (MOCEH) Prospective Study
| Autor: | Soo Jeong Lee, Kyoung Sook Jeong, Joseph Jeong, Ja Hyeong Kim, Mina Ha, Bo-Eun Lee, Eun-Hee Ha, Hyesook Park, Soo Young Bhang, Yangho Kim, Yun-Chul Hong, Boong Nyun Kim, Kyung Yeon Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Mothers Bayley Scales of Infant Development Cohort Studies 03 medical and health sciences 0302 clinical medicine Child Development Malondialdehyde Surveys and Questionnaires Epidemiology Oxidation medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Depression (differential diagnoses) Psychomotor learning business.industry Depression Antenatal Stress Infant General Medicine Child development Occupation & Environmental Medicine Cognitive Development Lead Linear Models Original Article Female business Psychosocial 030217 neurology & neurosurgery Stress Psychological Cohort study Cadmium |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Our objective is to evaluate the relationships between prenatal maternal stress and depressive symptoms, respectively, and infant neurodevelopment at 6 months, adjusted for heavy metals and oxidative stress. This research is a part of a multi-center birth cohort study in South Korea. Information on stress and depressive symptoms was collected during the first trimester using Psychosocial Well-Being Index Short Form (PWI-SF) and Center for Epidemiological Studies Depression Scale (CES-D). The Korean Bayley Scales of Infant Development-II assessment (BSID-II), which includes the standardized mental development index (MDI) and psychomotor developmental index (PDI), and Korean Ages & Stages Questionnaires (K-ASQ) were applied to infants at six months of age. A higher index score indicates better development. Among 641 babies, 320 were female (50%). Maternal PWI ≥ 29 (vs. PWI ≤ 18) during early pregnancy was associated with a decrease in MDI scores of 5.37 points (P = 0.02) after adjusting for socioeconomic factors. Maternal CES-D ≥ 26 (vs. CES-D ≤ 10) during early pregnancy was associated with a decrease in MDI scores of 8.18 points (P = 0.01). The associations remained significant even after adjustment for lead, cadmium, and MDA levels (P < 0.05). However, no association was found between maternal PWI/CES-D and PDI score. No interaction was observed between stress and lead exposure. We found an inverse association between prenatal maternal stress and depressive symptoms, and MDI scores in 6-month-old infants after adjustment for prenatal lead exposure, which is known to affect cognitive function negatively. Graphical Abstract |
| Databáze: | OpenAIRE |
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