Poly(ester amide)–Bioactive Glass Hybrid Biomaterials for Bone Regeneration and Biomolecule Delivery
| Autor: | Kibret Mequanint, Neda Aslankoohi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Chemistry Biomolecule Biochemistry (medical) Biomedical Engineering Nanotechnology 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Bone tissue engineering 0104 chemical sciences law.invention Biomaterials chemistry.chemical_compound law Bioactive glass Amide 0210 nano-technology Bone regeneration |
| Zdroj: | ACS Applied Bio Materials. 3:3621-3630 |
| ISSN: | 2576-6422 |
| Popis: | Designing bioactive materials for repairing or regenerating bone defects is an active area of research and discovery. Despite advances made in sol-gel-derived hybrid biomaterials design, three challenges remain: (i) the choice of biodegradable polymers that can form a homogeneous solution in the presence of water is very limited, (ii) low-temperature (below 50 °C) incorporation of calcium into the inorganic matrix while having molecular-level mixing has proven to be a difficult task, and (iii) incorporation of drug-loaded mesoporous nanoparticles into polymer-bioactive glass hybrid scaffolds has not been achieved. In this study, we developed bioactive biomaterials for bone repair/regeneration from an α-amino acid-derived biodegradable poly(ester amide) (PEA) and a tertiary bioglass (SiO |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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