JC papovavirus large tumor (T)-antigen expression in brain tissue of acquired immune deficiency syndrome (AIDS) and non-AIDS patients with progressive multifocal leukoencephalopathy
| Autor: | Caroline F. Ryschkewitsch, Duard L. Walker, Henry deF. Webster, Gerald L. Stoner |
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| Rok vydání: | 1986 |
| Předmět: |
viruses
Central nervous system Biology Virus Fixatives Antigen Immunopathology medicine Humans Antigens Viral Tumor Acquired Immunodeficiency Syndrome Multidisciplinary Progressive multifocal leukoencephalopathy Leukoencephalopathy Progressive Multifocal JC Virus Infection Brain Cell Transformation Viral medicine.disease biology.organism_classification JC Virus Virology medicine.anatomical_structure Viral disease Polyomavirus Papovavirus Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 83:2271-2275 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.83.7.2271 |
| Popis: | Progressive multifocal leukoencephalopathy (PML) is a JC papovavirus infection of the central nervous system in immunocompromised patients. It is well established that demyelination in PML is caused by JC virus infection of oligodendroglia, but whether the nonstructural regulatory protein, large tumor (T) antigen, is detectable in infected human tissue was not known. Using a modification of the peroxidase-antiperoxidase technique, we found T antigen expressed in the nuclei of cells in virus-infected sites in five cases of PML studied, including two with acquired immune deficiency syndrome (AIDS). PML occurs in AIDS at a much higher frequency than in other immunosuppressive disorders, and PML in AIDS may represent a more severe form of JC virus infection of the central nervous system. |
| Databáze: | OpenAIRE |
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