| Autor: |
Cansu Hemsinlioglu, Nil Banu Pelit, Omur Selin Gunaydin, Nihal Ozturk Sahin, Esra Savas Karagacli, Sefa Onur Demir, Evren Safak, Raife Dilek Turan, Goncagul Celebi, Miyase Ezgi Kocaoglu Sen, Zeynep Torun, Utku Seyis, Rehile Zengin, Ayse Sesin Kocagoz, Caglar Cuhadaroglu, Nur Birgen, Siret Ratip, Ercument Ovali |
| Rok vydání: |
2023 |
| Popis: |
BACKGROUND The efficacy of SARS-CoV2 single donor convalescent plasma (CP) varied according to the application time and the amount of antibody that is administered. Single donor CP has some drawbacks; such as the insufficient levels of neutralizing antibody activities, the requirements of blood group compatibility, and the risk of infection transmission. In this study, the safety and efficacy of pathogen inactivated, isohemagglutinin-depleted (concentrated) and pooled CP product was investigated. METHODS A total of sixteen patients were treated with either single donor CP (n=9) or pathogen-free, concentrated, pooled CP (ACB-IP 1.0) (n=7). RESULTS Five out of six single donor plasma SARS-CoV2 antibody titers remained below 12 s/co, but the antibody titers of all ACB-IP 1.0 plasma were above 12 s/co. SARS-CoV2 total antibody titers of ACB-IP 1.0 plasma were statistically higher than the antibody titers of single donor CP. Mean total plasma neutralizing antibody activity of ACB-IP 1.0 plasma (1.5421) was found statistically higher than single donor CP (0.9642) in 1:256 dilution (ρ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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