EWING SARCOMA OF THE BONE IN CHILDREN UNDER 6 YEARS OF AGE
| Autor: | Antonio Perez Martinez, Maria Antonietta De Ioris, Arcangelo, Prete, Raffaele, Cozza, Marta, Podda, Carla, Manzitti, Andrea, Pession, Elisabetta, Schiavello, Benedetta, Contoli, Rita, Balter, Franca, Fagioli, Bisogno, Gianni, Loredana, Amoroso, Franco, Locatelli, Roberto, Luksch |
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| Přispěvatelé: | De Ioris MA, Prete A, Cozza R, Podda M, Manzitti C, Pession A, Schiavello E, Contoli B, Balter R, Fagioli F, Bisogno G, Amoroso L, Locatelli F, Luksch R. |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Genetics and Molecular Biology (all) medicine.medical_treatment Cancer Treatment lcsh:Medicine Kaplan-Meier Estimate Pediatrics Biochemistry Metastasis Surgical oncology Basic Cancer Research Bone and Soft Tissue Sarcomas lcsh:Science Child Multidisciplinary Sarcoma Combined Modality Therapy Oncology Italy Child Preschool Medicine Female Research Article medicine.medical_specialty Ewing Sarcoma Bone Neoplasms Sarcoma Ewing Disease-Free Survival Humans Infant Proportional Hazards Models Biochemistry Genetics and Molecular Biology (all) Agricultural and Biological Sciences (all) Ewing Internal medicine medicine Preschool Chemotherapy PROGNOSTIC-FACTORS FAMILY TUMORS IFOSFAMIDE ETOPOSIDE CYCLOPHOSPHAMIDE OSTEOSARCOMA CHEMOTHERAPY EXPERIENCE YOUNGER IMPACT Proportional hazards model business.industry lcsh:R Cancers and Neoplasms medicine.disease Confidence interval Surgery Radiation therapy Pediatric Oncology Localized disease lcsh:Q business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e53223 (2013) |
| Popis: | Background Ewing Sarcoma Family Tumours (ESFT) are rare in early childhood. The aim of this study was to report the clinical characteristics and outcome of children under 6 years of age affected by ESFT of the bone in Italy. Methods The records of all the children diagnosed with osseous ESFT in centres members of the Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP) from 1990 to 2008 were reviewed. The Kaplan–Meier method was used for estimating overall and progression-free survival (OS, PFS) curves; multivariate analyses were performed using Cox proportional hazards regression model. Results This study includes 62 patients. An axial primary localization was present in 66% of patients, with the primary site in the chest wall in 34%. Fourteen (23%) patients presented metastatic disease. The 5-year OS and PFS were 73% (95% confidence interval, CI, 58–83%) and 72% (95% CI 57–83%) for patients with localized disease and 38% (95% CI 17–60%) and 21% (95% CI 5–45%) for patients with metastatic disease. Metastatic spread, skull/pelvis/spine primary localization, progression during treatment and no surgery predicted worse survival (P |
| Databáze: | OpenAIRE |
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