Dilation of forearm blood vessels after angiotensin-converting-enzyme inhibition by captopril in hypertensive patients
| Autor: | Carlos R. Ayers, D W Johns, S C Williams |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Captopril Proline Angiotensin-Converting Enzyme Inhibitors Blood Pressure Hyperemia Peptidyl-Dipeptidase A Forearm Heart Rate Internal medicine Renin–angiotensin system Renin Internal Medicine medicine Prazosin Plethysmograph Humans cardiovascular diseases Aged biology business.industry Angiotensin-converting enzyme Middle Aged Plethysmography Vasodilation Blood pressure Endocrinology medicine.anatomical_structure Regional Blood Flow Hypertension Vascular resistance Cardiology biology.protein Female Basal Metabolism business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 6(4) |
| ISSN: | 0194-911X |
| Popis: | In eight hypertensive patients, forearm vascular tone was assessed by water plethysmography following inhibition of angiotensin II-converting-enzyme (ACE) activity with captopril. Acute captopril administration increased venous distensibility (VV30) and decreased forearm vascular resistance (FVR), while it lowered systemic blood pressure (BP). Alpha-one adrenergic receptor blockade by prazosin did not prevent captopril from decreasing vascular tone or lowering blood pressure (BP). Thus, captopril dilated both veins and arterioles. The primary mechanism of captopril's acute antihypertensive action did not involve inhibition of alpha1-adrenergic receptor activity. Moreover, captopril and prazosin together produced a greater reduction in BP and peripheral resistance than occurred with either agent alone. |
| Databáze: | OpenAIRE |
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