Knockdown of Upregulated Gene 11 (URG11) Inhibits Proliferation, Invasion, and β-Catenin Expression in Non-Small Cell Lung Cancer Cells
| Autor: | Gao-ming Xiao, Jiao Wu, Jinfeng Yang, Zhe-liang Liu, Yue-jun Chen, Lin-xian Wang, Huiping Sun |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Wnt/β-catenin signaling pathway Lung Neoplasms Proliferation Gene Expression Non-small cell lung cancer (NSCLC) Biology Article Mice 03 medical and health sciences 0302 clinical medicine Cyclin D1 Invasion Downregulation and upregulation Cell Movement In vivo Carcinoma Non-Small-Cell Lung Cell Line Tumor Upregulated gene 11 (URG11) medicine Animals Humans Gene Silencing Lung cancer neoplasms Wnt Signaling Pathway Gene beta Catenin Gene knockdown General Medicine medicine.disease Xenograft Model Antitumor Assays Molecular biology respiratory tract diseases Gene Expression Regulation Neoplastic Disease Models Animal 030104 developmental biology Oncology Cell culture Gene Knockdown Techniques 030220 oncology & carcinogenesis Catenin Trans-Activators |
| Zdroj: | Oncology Research |
| ISSN: | 0965-0407 |
| Popis: | Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, was found to be involved in the development and progression of several tumors. However, the role of URG11 in human non-small cell lung cancer (NSCLC) has not yet been determined. Therefore, the aim of the present study was to explore the role of URG11 in human NSCLC. Our results found that URG11 was highly expressed in human NSCLC tissues compared with matched normal lung tissues, and higher levels were found in NSCLC cell lines in comparison to the normal lung cell line. Moreover, we also found that knockdown of URG11 significantly inhibited proliferation, migration/invasion of NSCLC cells, as well as suppressed tumor growth in vivo. Furthermore, knockdown of URG11 suppressed the expression of β-catenin, c-Myc, and cyclin D1 in NSCLC cells. Taken together, the study reported here provided evidence that URG11 downregulation suppresses proliferation, invasion, and β-catenin expression in NSCLC cells. Thus, URG11 may be a novel potential therapeutic target for NSCLC. |
| Databáze: | OpenAIRE |
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