Reduction of syndecan-1 expression in differentiated type early gastric cancer and background mucosa with gastric cellular phenotype
| Autor: | Toshifumi Ashida, Hiroki Tanabe, Jiro Watari, Atsuo Maemoto, Naomi Shibata, Yusuke Saitoh, Tomoyuki Ohta, Yutaka Kohgo, Takeshi Obara, Tokiyoshi Ayabe, Kinichi Yokota, Atsumi Yasuda, Mikihiro Fujiya, Kotaro Okamoto, Yuhei Inaba |
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| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty animal structures Syndecans In situ hybridization Biology Adenocarcinoma Syndecan 1 Surgical oncology Stomach Neoplasms Internal medicine medicine Humans In Situ Hybridization Membrane Glycoproteins Cell adhesion molecule Cadherin Gastroenterology Hepatology Cadherins Phenotype Immunohistochemistry Early Gastric Cancer carbohydrates (lipids) Gene Expression Regulation Neoplastic Gastric Mucosa embryonic structures Cancer research Proteoglycans Syndecan-1 |
| Zdroj: | Journal of gastroenterology. 39(2) |
| ISSN: | 0944-1174 |
| Popis: | Syndecan-1 is known to play a role as a cell adhesion molecule, similar to E-cadherin, and is associated with the maintenance of epithelial morphology. The purpose of this study was to elucidate the role and alterations of syndecan-1 expression in comparison with those of E-cadherin in different cellular phenotypes of differentiated-type gastric cancers (DGCs).A total of 80 DGCs at an early stage, and their adjacent mucosa, were evaluated by both immunohistochemistry and in situ hybridization. Syndecan-1 and E-cadherin were assessed by immunohistochemical staining with an anti-syndecan-1 and an anti-E-cadherin antibody, respectively. Based on immunohistochemistry, DGCs and their surrounding mucosa were divided into four types: gastric type (G-type), ordinary type (O-type), complete-intestinal type (CI-type), and null type.The expression sites of syndecan-1 mRNA mostly coincided with those of syndecan-1 protein. Syndecan-1 expression was significantly lower in G-type cancers (30%) than in O- (81%) and CI-type cancers (92%) ( P = 0.0001 and P = 0.004, respectively), but E-cadherin did not show this result. In addition, syndecan-1 expression was significantly reduced in DGCs comprised partly of poorly differentiated adenocarcinoma or signet-ring cell carcinoma, compared to DGCs demonstrating papillary and/or tubular adenocarcinoma ( P = 0.02). G-type intestinal metaplasia (IM) surrounding the tumors was observed in 21% of G-type cancers, in 0% of O-, and in 10% of CI-type cancers ( P = 0.01; G-type vs O-type). Reduction of syndecan-1 expression was significant in G-type IM (25%) compared to non-G-type IM (75%; P = 0.02).Syndecan-1 plays a role in the growth of G-type cancers at an early stage compared with E-cadherin changes, and the reduction of syndecan-1 expression in IM surrounding the tumors may influence the growth of G-type cancer. |
| Databáze: | OpenAIRE |
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