Investigation of low levels of plasma valproic acid concentration following simultaneous administration of sodium valproate and rizatriptan benzoate
| Autor: | Susumu Ohshiro, Norio Hobara, Matao Sakanashi, Nobuo Hokama, Narumi Hobara, Hiromasa Kameya |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Monocarboxylic Acid Transporters medicine.medical_treatment Sodium Pharmaceutical Science chemistry.chemical_element Pharmacology Rats Sprague-Dawley chemistry.chemical_compound Pharmacokinetics Oral administration medicine Animals Drug Interactions Benzoic acid Valproic Acid Rizatriptan Benzoate Triazoles Drug interaction Tryptamines Rats Serotonin Receptor Agonists Anticonvulsant chemistry Anticonvulsants lipids (amino acids peptides and proteins) medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 59:383-386 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1211/jpp.59.3.0007 |
| Popis: | Drug interaction between rizatriptan benzoate, an anti-migraine agent, and sodium valproate (VPA-Na), an anticonvulsant, was studied in rats. When rizatriptan benzoate was administered orally immediately after VPA-Na oral administration, the pharmacokinetic parameters, such as plasma valproic acid (VPA) and area under the plasma concentration-time curve up to 3 h (AUC0–3), were significantly decreased compared with those in the control group. However, when rizatriptan benzoate was administered intraperitoneally immediately after VPA-Na orally, these parameters were not changed. In addition, when benzoic acid was administered orally immediately after VPA-Na orally, these were significantly lower compared with the control values. Therefore, it might be possible that VPA transport by monocarboxylate transporter was competitively inhibited by rizatriptan benzoate and thus absorption of VPA was decreased. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text