Hypercalcemia and abnormal 1,25-dihydroxyvitamin D concentrations in leprosy
| Autor: | Frederick R. Singer, Elisabeth Ryzen, Thomas H. Rea |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system Parathyroid hormone Pathogenesis Excretion Hydroxyproline chemistry.chemical_compound Calcitriol Prednisone Leprosy Internal medicine Cyclic AMP medicine Humans Cyclic adenosine monophosphate Lepromatous leprosy business.industry General Medicine medicine.disease Endocrinology chemistry Parathyroid Hormone Hypercalcemia business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The American Journal of Medicine. 84:325-329 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(88)90434-2 |
| Popis: | Two patients with lepromatous leprosy and hypercalcemia are presented. Serum immunoreactive parathyroid hormone and urinary cyclic adenosine monophosphate concentrations were suppressed. Serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations were elevated in one patient and normal in the other. Urinary hydroxyproline excretion was slightly high in both patients. Hypercalcemia resolved excretion was slightly high in both patients. Hypercalcemia resolved with prednisone therapy. Abnormal 1,25-(OH)2D production and/or metabolism may play a role in the pathogenesis of hypercalcemia in some patients with leprosy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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